Possible participation of D-3 and D-4 dopaminergic receptors on genital reflexes induced by cocaine in paradoxical sleep deprived male rats

Possible participation of D-3 and D-4 dopaminergic receptors on genital reflexes induced by cocaine in paradoxical sleep deprived male rats

Author Andersen, Monica L. Google Scholar
Perry, Juliana C. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Previous studies have demonstrated that paradoxical sleep deprivation (PSD) potentiates cocaine-induced genital reflexes in male rats and both D-1 and D-2 receptors may play a role in those effects, and to examine the possibility that such might involve other dopaminergic receptors, we investigated the effects of D-3 and D-4 receptor subtype antagonists on cocaine-induced reflexes in sleep-deprived rats. Separate groups of PSD rats received saline, D-3 (U9919A; 0.75, 1.5 and 3 mg/kg) or D-4 (L745870; 0.75, 1.5 and 3 mg/kg) antagonists prior to acute cocaine challenge. Results demonstrated that U9919A induced significant reduction in the number of animals that displayed erection and the frequency of erection at two smaller doses, while no significant difference was reported for the D-4 receptor antagonist. Although our studies indicate that there is a relevant participation of D-3 receptors in male sexual function, D-4 receptors seem not to exert an essential role in this model.
Keywords sleep deprivation
dopamine
D-3 receptors
D-4 receptors
erection
cocaine
Language English
Date 2007-12-01
Published in Scandinavian Journal of Psychology. Oxford: Blackwell Publishing, v. 48, n. 6, p. 443-447, 2007.
ISSN 0036-5564 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 443-447
Origin http://dx.doi.org/10.1111/j.1467-9450.2007.00613.x
Access rights Closed access
Type Article
Web of Science ID WOS:000251206800001
URI http://repositorio.unifesp.br/handle/11600/30200

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