Skeletal muscle ergoreflex overactivity is not related to exercise ventilatory inefficiency in non-hypoxaemic patients with COPD

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dc.contributor.author Nakamoto, Fernanda Patti
dc.contributor.author Neder, J. Alberto
dc.contributor.author Maia, Joyce
dc.contributor.author Andrade, Marilia S.
dc.contributor.author Silva, Antonio Carlos
dc.date.accessioned 2016-01-24T13:49:14Z
dc.date.available 2016-01-24T13:49:14Z
dc.date.issued 2007-12-01
dc.identifier http://dx.doi.org/10.1007/s00421-007-0543-3
dc.identifier.citation European Journal of Applied Physiology. New York: Springer, v. 101, n. 6, p. 705-712, 2007.
dc.identifier.issn 1439-6319
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30174
dc.description.abstract Increased ventilatory response to the metabolic demand (ventilatory inefficiency) is commonly found during dynamic exercise in patients with chronic obstructive pulmonary disease (COPD). However, the role of enhanced muscle ergoreflex activity on this phenomenon is yet unknown. Ten non-hypoxaemic patients with varying degrees of disease severity (median and range of post-bronchodilator FEV1 = 37.5 (27 to 70%) predicted) and 7 age-and gender-matched controls were studied. Subjects were submitted to wrist flexion tests to the limit of tolerance (Tlim) with and without post-exercise regional circulatory occlusion (PE-RCO) for 3 min. the muscle ergoreflex activity was quantified as the difference in ventilation between PE-RCO and control recovery periods corrected for the resting values (ergoreflex D). in addition, the area under the ventilatory curve in the recovery period was calculated in both conditions. We found that Tlim and the physiological stress associated with localized exercise did not differ between patients and controls. However, patients had increased ventilatory response to a given metabolic demand (VCO2), either at rest or during exercise (P < 0.05). There were no significant differences in ergoreflex Delta in patients and controls (-2.2 to 2.4 (0.2) vs.-0.6 to 1.8 (0.3) l/min, respectively). in addition, the area under the ventilatory curve in the recovery period did not differ between control and PE-RCO tests in patients and healthy subjects (P > 0.05). We conclude that increased muscle ergoreflex activity did not contribute to an excessive ventilatory response to exercise in patients with COPD-at least in non-hypoxaemic and non-cachetic subjects. en
dc.format.extent 705-712
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof European Journal of Applied Physiology
dc.rights Acesso restrito
dc.subject ventilation en
dc.subject muscles en
dc.subject exercise en
dc.subject COPD en
dc.subject ergoreflex en
dc.title Skeletal muscle ergoreflex overactivity is not related to exercise ventilatory inefficiency in non-hypoxaemic patients with COPD en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Physiol, Resp & Exercise Physiol Lab, Neurophysiol & Exercise Physiol Div, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Resp Dis Studies, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Physiol, Resp & Exercise Physiol Lab, Neurophysiol & Exercise Physiol Div, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Resp Dis Studies, São Paulo, Brazil
dc.identifier.doi 10.1007/s00421-007-0543-3
dc.description.source Web of Science
dc.identifier.wos WOS:000250117200006



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