Antiretroviral drug therapy alters the profile of human immunodeficiency virus type 1-specific T-cell responses and shifts the immunodominant cytotoxic T-lymphocyte response from gag to pol

Antiretroviral drug therapy alters the profile of human immunodeficiency virus type 1-specific T-cell responses and shifts the immunodominant cytotoxic T-lymphocyte response from gag to pol

Author Karlsson, A. C. Google Scholar
Chapman, J. M. Google Scholar
Heiken, B. D. Google Scholar
Hoh, R. Google Scholar
Kallas, E. G. Autor UNIFESP Google Scholar
Martin, J. N. Google Scholar
Hecht, F. M. Google Scholar
Deeks, S. G. Google Scholar
Nixon, D. F. Google Scholar
Institution Univ Calif San Francisco
Karolinska Inst
San Francisco Gen Hosp
Universidade Federal de São Paulo (UNIFESP)
Abstract Antiretroviral drug therapy and cytotoxic T lymphocytes (CTL) both exert selective pressures on human immunodeficiency virus type 1, which influence viral evolution. Compared to chronically infected, antiretroviral-untreated patients, most chronically infected, treated patients with detectable viremia lack a cellular immune response against the Gag 77-85(SL9) epitope but show a new immunodominant response against an epitope in protease PR 76-84. Hence, mutations induced by antiretroviral therapy likely alter the profile of epitopes presented to T cells and thus the direction of the response. the consequences of dual pressures from treatment and CTL need to be considered in monitoring of drug therapy.
Language English
Date 2007-10-01
Published in Journal of Virology. Washington: Amer Soc Microbiology, v. 81, n. 20, p. 11543-11548, 2007.
ISSN 0022-538X (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 11543-11548
Origin http://dx.doi.org/10.1128/JVI.00779-07
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000250019400069
URI http://repositorio.unifesp.br/handle/11600/30057

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