Physical exercise program reverts the effects of pinealectomy on the amygdala kindling development

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dc.contributor.author Silva de Lacerda, Aline Fabiana
dc.contributor.author Janjoppi, Luciana
dc.contributor.author Scorza, Fulvio Alexandre
dc.contributor.author Lima, Eliangela
dc.contributor.author Amado, Debora
dc.contributor.author Cavalheiro, Esper Abrao
dc.contributor.author Arida, Ricardo Mario
dc.date.accessioned 2016-01-24T13:49:05Z
dc.date.available 2016-01-24T13:49:05Z
dc.date.issued 2007-09-28
dc.identifier http://dx.doi.org/10.1016/j.brainresbull.2007.06.011
dc.identifier.citation Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 74, n. 4, p. 216-220, 2007.
dc.identifier.issn 0361-9230
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30048
dc.description.abstract Several studies have demonstrated the anticonvulsant effect of melatonin. in view of the positive effects of physical exercise in epilepsy, this study analyzed the influence of physical exercise program on the amygdala kindling development in pinealectomized rats. Animals were divided into six groups: pinealectomized rats (PX), sham rats (SHAM), control rats (CTL), pinealectomized rats submitted to an aerobic exercise program (PX ATL), sham rats submitted to an aerobic exercise program (SHAM ATL) and control rats submitted to an aerobic exercise pro-ram (CTL ATL). the stimulus parameters consisted of 60 Hz frequency, diphasic square pulses of I ms duration applied for 2 s. the mean number of stimulations and the after-discharge (AD) duration for each stage of kindling were similar among CTL and SHAM animals. PX animals showed particular characteristics during kindling development. They did not present stage 1 and spent a shorter time in stage 2 in relation to the CTL and SHAM animals. Consequently, the AD duration and number of stimulations required to reach stage 5 was lower for the PX group when compared to the CTL and SHAM groups. Concerning the exercising groups, CTL ATL and SHAM ATL animals spent a higher time in stage I compared to CTL and SHAM groups. Thus, CTL ATL animals also presented a higher number of stimulations in stage 5 compared to CTL animals. the stage 1 not observed in PX animals was present in PX ATL. Consequently, the number of stimulations required to reach stage 5 was statistically higher for the PX ATL group in relation to the PX group. Our results demonstrate that the acceleration in the kindling development of pinealectomized animals can be reverted by physical exercise. (c) 2007 Elsevier Inc. All rights reserved. en
dc.format.extent 216-220
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research Bulletin
dc.rights Acesso restrito
dc.subject melatonin en
dc.subject pinealectomy en
dc.subject kindling en
dc.subject epilepsy en
dc.subject physical exercise en
dc.subject rat en
dc.title Physical exercise program reverts the effects of pinealectomy on the amygdala kindling development en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.brainresbull.2007.06.011
dc.description.source Web of Science
dc.identifier.wos WOS:000249750500003



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