Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas

Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas

Author Ierardi, D. F. Google Scholar
Fernandes, M. J. S. Google Scholar
Silva, I. R. Google Scholar
Thomazini-Gouveia, J. Google Scholar
Silva, Nasjla Saba Google Scholar
Dastoli, Patricia Google Scholar
Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Cavalheiro, Sergio Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objectives the aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway.Materials and methods Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha. the tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.Results There was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. the concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.Conclusions Our data demonstrated that the IFN-a was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy.
Keywords cystic craniopharyngioma
alpha interferon apoptosis
Fas/FasL pathway
intratumoral chemotherapy
cell death pathways
Ommaya reservoir
Language English
Date 2007-09-01
Published in Childs Nervous System. New York: Springer, v. 23, n. 9, p. 1041-1046, 2007.
ISSN 0256-7040 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1041-1046
Origin http://dx.doi.org/10.1007/s00381-007-0409-3
Access rights Closed access
Type Article
Web of Science ID WOS:000249017700014
URI http://repositorio.unifesp.br/handle/11600/29998

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