Co-infection with Trypanosoma cruzi protects mice against early death by neurological or pulmonary disorders induced by Plasmodium berghei ANKA

Co-infection with Trypanosoma cruzi protects mice against early death by neurological or pulmonary disorders induced by Plasmodium berghei ANKA

Author Egima, Claudia M. Autor UNIFESP Google Scholar
Macedo, Silene F. Autor UNIFESP Google Scholar
Sasso, Gisela R. S. Autor UNIFESP Google Scholar
Covarrubias, Charles Autor UNIFESP Google Scholar
Cortez, Mauro Autor UNIFESP Google Scholar
Maeda, Fernando Y. Autor UNIFESP Google Scholar
Costa, Fabio Trindade Maranhão Autor UNIFESP Google Scholar
Yoshida, Nobuko Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract Objective: the objective of this study was to investigate whether the infection of C57BL/ 6 mice by P. berghei ANKA, which causes severe malaria, was modulated by co-infection with Trypanosoma cruzi.Methods: Groups of C57BL/ 6 mice were infected either with P. berghei ANKA, T. cruzi strain G, or with both parasites. the presence of parasites was checked by microscopic examination of blood samples. Symptoms of neurological or respiratory disorders, as well as mortality, were registered. Breakdown of the blood brain barrier was determined by injecting the dye Evans blue. Histological sections of the lung were prepared and stained with hematoxilin-eosin.Results: All mice infected only with P. berghei ANKA died within 7-11 days post-infection, either with symptoms of cerebral malaria or with respiratory abnormalities. the animals co- infected with T. cruzi strain G survived longer, without any of the referred to symptoms. Protection against the early death by severe malaria was effective when mice were given T. cruzi 15 days before P. berghei inoculation. Breakdown of the blood brain barrier and extensive pulmonary oedema, caused by malaria parasites, were much less pronounced in co- infected mice. the degree of protection to severe malaria and early death, conferred by co- infection with T. cruzi, was comparable to that conferred by treatment with anti-CD8 antibodies.Conclusion: Co-infection with T. cruzi protects C57BL/ 6 against the early death by malaria infection, by partially preventing either the breakdown of the blood brain, and cerebral malaria as a consequence, or the pulmonary oedema.
Language English
Date 2007-07-09
Published in Malaria Journal. London: Biomed Central Ltd, v. 6, 6 p., 2007.
ISSN 1475-2875 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 6
Origin http://dx.doi.org/10.1186/1475-2875-6-90
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000249300000001
URI http://repositorio.unifesp.br/handle/11600/29873

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