FLT3 mutation and AML/ETO in a case of Myelodysplastic syndrome in transformation corroborates the two hit model of leukemogenesis

FLT3 mutation and AML/ETO in a case of Myelodysplastic syndrome in transformation corroborates the two hit model of leukemogenesis

Autor Feitosa Pinheiro, Ronald Google Scholar
Sa Moreira, Eloisa de Google Scholar
Regis Silva, Maria Regina Google Scholar
Greggio, Barbara Google Scholar
Lopes Alberto, Fernando Google Scholar
Chauffaille, Maria de Lourdes L. F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The aim of this report is to present a case of Myelodysplastic syndrome (MIDS) who presented, during AML transformation, a step-wise genetic progression that corroborates the two hit model of leukemogenesis. A RCDM-RS (WHO)/RARS (FAB) patient with normal karyotype at diagnosis. evolved into AML after six months of follow up. At transformation, AML/ETO fusion was detected, although marrow blast cells were not increased until 21 days later. when FLT3-ITD was also demonstrated pointing Out that the overgrowth of the FLT3/ITD clone was concomitant with the outburst of marrow blasts. These findings corroborates the two hit model of leukemogenesis in which one class of mutations (Class I) (FLT3/ITD) confers a proliferative or Survival advantage to cells, and a second class of mutations (Class II) (AML/ETO) interferes with hematopoietic differentiation. (C) 2006 Elsevier B.V. All rights reserved.
Assunto FLT3
MDS
AML/ETO
AML
Idioma Inglês
Data 2007-07-01
Publicado em Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 31, n. 7, p. 1015-1018, 2007.
ISSN 0145-2126 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 1015-1018
Fonte http://dx.doi.org/10.1016/j.leukres.2006.09.018
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000247764300019
URI http://repositorio.unifesp.br/handle/11600/29858

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