Greater cortical gray matter density in lithium-treated patients with bipolar disorder

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dc.contributor.author Bearden, Carrie E.
dc.contributor.author Thompson, Paul M.
dc.contributor.author Dalwani, Manish
dc.contributor.author Hayashi, Kiralee M.
dc.contributor.author Lee, Agatha D.
dc.contributor.author Nicoletti, Mark
dc.contributor.author Trakhtenbroit, Michael
dc.contributor.author Glahn, David C.
dc.contributor.author Brambilla, Paolo
dc.contributor.author Sassi, Roberto B.
dc.contributor.author Mallinger, Alan G.
dc.contributor.author Frank, Ellen
dc.contributor.author Kupfer, David J.
dc.contributor.author Soares, Jair C.
dc.date.accessioned 2016-01-24T13:48:51Z
dc.date.available 2016-01-24T13:48:51Z
dc.date.issued 2007-07-01
dc.identifier http://dx.doi.org/10.1016/j.biopsych.2006.10.027
dc.identifier.citation Biological Psychiatry. New York: Elsevier B.V., v. 62, n. 1, p. 7-16, 2007.
dc.identifier.issn 0006-3223
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29852
dc.description.abstract Background: the neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures.Methods: We used high-resolution magnetic resonance imaging and cortical pattern matching methods to map gray matter differences in 28 adults with bipolar disorder, 70% of whom were lithium-treated (mean age = 36.1 +/- 10.5; 13 female subject), and 28 healthy control subjects (mean age = 35.9 +/- 8.5; 11 female subjects). Detailed spatial analyses of gray matter density (GMD) were conducted by measuring local proportions of gray matter at thousands of homologous cortical locations.Results: Gray matter density was significantly greater in bipolar patients relative to control subjects in diffuse cortical regions. Greatest differences were found in bilateral cingulate and paralimbic cortices, brain regions critical for attentional, motivational, and emotional modulation. Secondary region of interest (1301) analyses indicated significantly greater GMD in the right anterior cingulate among lithium-treated bipolar patients (n = 20) relative to those not taking lithium (n = 8).Conclusions: These brain maps are consistent with previous voxel-based morphometry reports of greater GMD in portions of the anterior limbic network in bipolar patients and suggest neurotrophic effects of lithium as a possible etiology of these neuroanatomic differences. en
dc.format.extent 7-16
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Biological Psychiatry
dc.rights Acesso restrito
dc.subject bipolar disorder en
dc.subject cortical pattern matching en
dc.subject lithium en
dc.subject magnetic resonance imaging en
dc.subject mood disorders en
dc.subject neuroprotection en
dc.title Greater cortical gray matter density in lithium-treated patients with bipolar disorder en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Univ Calif Los Angeles
dc.contributor.institution Univ Texas
dc.contributor.institution Univ Udine
dc.contributor.institution IRCCS
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Pittsburgh
dc.contributor.institution S Texas Vet Hlth Care Syst
dc.description.affiliation Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA
dc.description.affiliation Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Behav Sci, Lab Neurolmaging, Los Angeles, CA USA
dc.description.affiliation Univ Texas, Hlth Sci Ctr, Dept Psychiat, San Antonio, TX USA
dc.description.affiliation Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX USA
dc.description.affiliation Univ Udine, Dept Pathol & Expt & Clin Med, I-33100 Udine, Italy
dc.description.affiliation IRCCS, Inst Sci, Udine, Italy
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.affiliation Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
dc.description.affiliation S Texas Vet Hlth Care Syst, San Antonio, TX USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi 10.1016/j.biopsych.2006.10.027
dc.description.source Web of Science
dc.identifier.wos WOS:000247653500003



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