Greater cortical gray matter density in lithium-treated patients with bipolar disorder

Greater cortical gray matter density in lithium-treated patients with bipolar disorder

Author Bearden, Carrie E. Google Scholar
Thompson, Paul M. Google Scholar
Dalwani, Manish Google Scholar
Hayashi, Kiralee M. Google Scholar
Lee, Agatha D. Google Scholar
Nicoletti, Mark Google Scholar
Trakhtenbroit, Michael Google Scholar
Glahn, David C. Google Scholar
Brambilla, Paolo Google Scholar
Sassi, Roberto B. Google Scholar
Mallinger, Alan G. Google Scholar
Frank, Ellen Google Scholar
Kupfer, David J. Google Scholar
Soares, Jair C. Google Scholar
Institution Univ Calif Los Angeles
Univ Texas
Univ Udine
Universidade Federal de São Paulo (UNIFESP)
Univ Pittsburgh
S Texas Vet Hlth Care Syst
Abstract Background: the neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures.Methods: We used high-resolution magnetic resonance imaging and cortical pattern matching methods to map gray matter differences in 28 adults with bipolar disorder, 70% of whom were lithium-treated (mean age = 36.1 +/- 10.5; 13 female subject), and 28 healthy control subjects (mean age = 35.9 +/- 8.5; 11 female subjects). Detailed spatial analyses of gray matter density (GMD) were conducted by measuring local proportions of gray matter at thousands of homologous cortical locations.Results: Gray matter density was significantly greater in bipolar patients relative to control subjects in diffuse cortical regions. Greatest differences were found in bilateral cingulate and paralimbic cortices, brain regions critical for attentional, motivational, and emotional modulation. Secondary region of interest (1301) analyses indicated significantly greater GMD in the right anterior cingulate among lithium-treated bipolar patients (n = 20) relative to those not taking lithium (n = 8).Conclusions: These brain maps are consistent with previous voxel-based morphometry reports of greater GMD in portions of the anterior limbic network in bipolar patients and suggest neurotrophic effects of lithium as a possible etiology of these neuroanatomic differences.
Keywords bipolar disorder
cortical pattern matching
magnetic resonance imaging
mood disorders
Language English
Date 2007-07-01
Published in Biological Psychiatry. New York: Elsevier B.V., v. 62, n. 1, p. 7-16, 2007.
ISSN 0006-3223 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 7-16
Access rights Closed access
Type Article
Web of Science ID WOS:000247653500003

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account