c-Myc-dependent formation of robertsonian translocation chromosomes in mouse cells

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dc.contributor.author Guffei, Amanda
dc.contributor.author Lichtensztejn, Zelda
dc.contributor.author Silva, Amanda Goncalves dos Santos [UNIFESP]
dc.contributor.author Louis, Sherif F.
dc.contributor.author Caporali, Andrea
dc.contributor.author Mai, Sabine
dc.date.accessioned 2016-01-24T13:48:49Z
dc.date.available 2016-01-24T13:48:49Z
dc.date.issued 2007-07-01
dc.identifier http://dx.doi.org/10.1593/neo.07355
dc.identifier.citation Neoplasia. Ann Arbor: Neoplasia Press, v. 9, n. 7, p. 578-U1, 2007.
dc.identifier.issn 1522-8002
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29836
dc.description.abstract Robertsonian (Rb) translocation chromosomes occur in human and murine cancers and involve the aberrant joining of two acrocentric chromosomes in humans and two telocentric chromosomes in mice. Mechanisms leading to their generation remain elusive, but models for their formation have been proposed. They include breakage of centromeric sequences and their subsequent fusions, centric misdivision, misparing between highly repetitive sequences of p- tel or p- arm repeats, and recombinational joining of centromeres and/ or centromeric fusions. Here, we have investigated the role of the oncoprotein c- Myc in the formation of Rb chromosomes in mouse cells harboring exclusively telocentric chromosomes. in mouse plasmacytoma cells with constitutive c- Myc deregulation and in immortalized mouse lymphocytes with conditional c-Myc expression, we show that positional remodeling of centromeres in interphase nuclei coincides with the formation of Rb chromosomes. Furthermore, we demonstrate that c-Myc deregulation in a myc box II - dependent manner is sufficient to induce Rb translocation chromosomes. Because telomeric signals are present at all joined centromeres of Rb chromosomes, we conclude that c-Myc mediates Rb chromosome formation in mouse cells by telomere fusions at centromeric termini of telocentric chromosomes. Our findings are relevant to the understanding of nuclear chromosome remodeling during the initiation of genomic instability and tumorigenesis. en
dc.format.extent 578-U1
dc.language.iso eng
dc.publisher Neoplasia Press
dc.relation.ispartof Neoplasia
dc.rights Acesso aberto
dc.subject centromere en
dc.subject nuclear organization en
dc.subject Robertsonian chromosome en
dc.subject c-Myc en
dc.subject genomic instability en
dc.title c-Myc-dependent formation of robertsonian translocation chromosomes in mouse cells en
dc.type Artigo
dc.contributor.institution Univ Manitoba
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Parma
dc.description.affiliation Univ Manitoba, Manitoba Inst Cell Biol, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Imunol, BR-04023062 São Paulo, Brazil
dc.description.affiliation Univ Parma, Dipartimento Med Sperimentale, Sez Biochim Biochim Clin & Biochim Esercizo Fis, I-43100 Parma, Italy
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Disciplina Imunol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1593/neo.07355
dc.description.source Web of Science
dc.identifier.wos WOS:000248495100007



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