Characterization and functions of beta defensins in the epididymis

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dc.contributor.author Hall, Susan H.
dc.contributor.author Yenugu, Suresh
dc.contributor.author Radhakrishnan, Yashwanth
dc.contributor.author Avellar, Maria Christina Werneck [UNIFESP]
dc.contributor.author Petrusz, Peter
dc.contributor.author French, Frank S.
dc.date.accessioned 2016-01-24T13:48:49Z
dc.date.available 2016-01-24T13:48:49Z
dc.date.issued 2007-07-01
dc.identifier http://dx.doi.org/10.1111/j.1745-7262.2007.00298.x
dc.identifier.citation Asian Journal of Andrology. Mumbai: Medknow Publications & Media Pvt Ltd, v. 9, n. 4, p. 453-462, 2007.
dc.identifier.issn 1008-682X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29830
dc.description.abstract The epididymal beta-defensins have evolved by repeated gene duplication and divergence to encode a family of proteins that provide direct protection against pathogens and also support the male reproductive tract in its primary function. Male tract defensins also facilitate recovery from pathogen attack. the beta-defensins possess ancient conserved sequence and structural features widespread in multi-cellular organisms, suggesting fundamental roles in species survival. Primate SPAG11, the functional fusion of two ancestrally independent beta-defensin genes, produces a large family of alternatively spliced transcripts that are expressed according to tissue-specific and species-specific constraints. the complexity of SPAG11 varies in different branches of mammalian evolution. Interactions of human SPAG11D with host proteins indicate involvement in multiple signaling pathways. en
dc.format.extent 453-462
dc.language.iso eng
dc.publisher Medknow Publications & Media Pvt Ltd
dc.relation.ispartof Asian Journal of Andrology
dc.rights Acesso aberto
dc.subject defensin en
dc.subject antibacterial en
dc.subject male fertility en
dc.title Characterization and functions of beta defensins in the epididymis en
dc.type Resenha
dc.contributor.institution Univ N Carolina
dc.contributor.institution Pondicherry Cent Univ
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ N Carolina, Reprod Biol Lab, Chapel Hill, NC 27599 USA
dc.description.affiliation Pondicherry Cent Univ, Dept Biochem & Mol Biol, Pondicherry 605014, India
dc.description.affiliation Universidade Federal de São Paulo, Dept Pharmacol, Sect Expt Endocrinol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pharmacol, Sect Expt Endocrinol, BR-04044020 São Paulo, Brazil
dc.identifier.file WOS000247752800004.pdf
dc.identifier.doi 10.1111/j.1745-7262.2007.00298.x
dc.description.source Web of Science
dc.identifier.wos WOS:000247752800004



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