Characterization and functions of beta defensins in the epididymis

Characterization and functions of beta defensins in the epididymis

Author Hall, Susan H. Google Scholar
Yenugu, Suresh Google Scholar
Radhakrishnan, Yashwanth Google Scholar
Avellar, Maria Christina Werneck Autor UNIFESP Google Scholar
Petrusz, Peter Google Scholar
French, Frank S. Google Scholar
Institution Univ N Carolina
Pondicherry Cent Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract The epididymal beta-defensins have evolved by repeated gene duplication and divergence to encode a family of proteins that provide direct protection against pathogens and also support the male reproductive tract in its primary function. Male tract defensins also facilitate recovery from pathogen attack. the beta-defensins possess ancient conserved sequence and structural features widespread in multi-cellular organisms, suggesting fundamental roles in species survival. Primate SPAG11, the functional fusion of two ancestrally independent beta-defensin genes, produces a large family of alternatively spliced transcripts that are expressed according to tissue-specific and species-specific constraints. the complexity of SPAG11 varies in different branches of mammalian evolution. Interactions of human SPAG11D with host proteins indicate involvement in multiple signaling pathways.
Keywords defensin
antibacterial
male fertility
Language English
Date 2007-07-01
Published in Asian Journal of Andrology. Mumbai: Medknow Publications & Media Pvt Ltd, v. 9, n. 4, p. 453-462, 2007.
ISSN 1008-682X (Sherpa/Romeo, impact factor)
Publisher Medknow Publications & Media Pvt Ltd
Extent 453-462
Origin http://dx.doi.org/10.1111/j.1745-7262.2007.00298.x
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000247752800004
URI http://repositorio.unifesp.br/handle/11600/29830

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