Expression of major vault protein gene in osteosarcorna patients

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dc.contributor.author Dalla Torre, Cristiane Arruda [UNIFESP]
dc.contributor.author Toledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.author Yoshimoto, Maisa
dc.contributor.author Petrilli, Antonio Sergio [UNIFESP]
dc.contributor.author Andrade, Joyce Anderson Duffles [UNIFESP]
dc.contributor.author Chilton-MacNeill, Susan
dc.contributor.author Squire, Jeremy A.
dc.contributor.author Zielenska, Maria
dc.date.accessioned 2016-01-24T13:48:49Z
dc.date.available 2016-01-24T13:48:49Z
dc.date.issued 2007-07-01
dc.identifier http://dx.doi.org/10.1002/jor.20371
dc.identifier.citation Journal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 7, p. 958-963, 2007.
dc.identifier.issn 0736-0266
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29826
dc.description.abstract Osteosarcoma (CS) is a primary malignant tumor of bone. Despite the successful use of multiple chemotherapeutic agents in the treatment of OS, more than 30% of OS tumors remain resistant to treatment. Elucidation of cellular resistance mechanisms may lead to better treatments for cancer patients. in this study, we used the low-density expression cDNA array, GEArray Q Series Human Cancer Drug Resistance and Metabolism Gene Array to screen genes related to drug resistance in 15 OS tumors. Expression patterns of the MPV gene were validated by real time PCR on 45 OS patient tumor samples and correlated with clinical and pathological data. Major vault protein (MVP) expression was present in 24 (53%) tumor samples and absent in 21 (47%). Samples from surgery showed correlation between the expression of MVP, metastatic disease at diagnosis and event free survival (EFS). the MVP gene expression correlates with metastatic disease at diagnosis after neoadjuvant chemotherapy (p = 0.048), and is also associated with worse EFS (p = 0.036). These findings suggest that MVP expression is involved in one of the mechanisms of drug resistance in OS and is induced by chemotherapy. (c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. en
dc.format.extent 958-963
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Orthopaedic Research
dc.rights Acesso aberto
dc.subject osteosarcoma en
dc.subject MVP gene en
dc.subject drug resistance en
dc.subject gene expression en
dc.title Expression of major vault protein gene in osteosarcorna patients en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Princess Margaret Hosp
dc.contributor.institution Hosp Sick Children
dc.contributor.institution Univ Toronto
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, IOP, GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Morphol, Div Genet, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliation Princess Margaret Hosp, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
dc.description.affiliation Hosp Sick Children, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada
dc.description.affiliation Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 2M9, Canada
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, IOP, GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Morphol, Div Genet, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1002/jor.20371
dc.description.source Web of Science
dc.identifier.wos WOS:000247262300014



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