The Role of the Substantia Nigra Pars Compacta in Regulating Sleep Patterns in Rats

Show simple item record Lima, Marcelo M. S. [UNIFESP] Andersen, Monica L. [UNIFESP] Reksidler, Angela B. Vital, Maria A. B. F. Tufik, Sergio [UNIFESP] 2016-01-24T13:48:48Z 2016-01-24T13:48:48Z 2007-06-06
dc.identifier.citation Plos One. San Francisco: Public Library Science, v. 2, n. 6, 7 p., 2007.
dc.identifier.issn 1932-6203
dc.description.abstract Background. As of late, dopaminergic neurotransmission has been recognized to be involved in the generation of sleep disturbances. Increasing evidence shows that sleep disturbances in Parkinson's disease (PD) patients are mostly related to the disease itself, rather than being a secondary phenomenon. Evidence contained in the literature lends support to the hypothesis that the dopaminergic nigrostriatal pathway is closely involved in the regulation of sleep patterns. Methodology/Principal Findings. To test this hypothesis we examined the electrophysiological activity along the sleep-wake cycle of rats submitted to a surgically induced lesion of the SNpc by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We demonstrated that a 50% lesion of the substantia nigra pars compacta (SNpc) suffices to produce disruptions of several parameters in the sleep-wake pattern of rats. A robust and constant decrease in the latency to the onset of slow wave sleep (SWS) was detected throughout the five days of recording in both light [F((22.16)) = 72.46, p<0.0001] and dark [F((22.16)) = 75.0, p<0.0001] periods. Also found was a pronounced increase in the percentage of sleep efficiency during the first four days of recording [F((21.15)) = 21.48, p<0.0001], in comparison to the sham group. Additionally, the reduction in the SNpc dopaminergic neurons provoked an ablation in the percentage of rapid eye movement sleep (REM) during three days of the sleep-wake recording period with a strong correlation (r = 0.91; p<0.0001) between the number of dopaminergic neurons lost and the percentage decrease of REM sleep on the first day of recording. On day 4, the percentage of REM sleep during the light and dark periods was increased, [F((22.16)) = 2.46, p<0.0007], a phenomenon consistent with REM rebound. Conclusions/Significance. We propose that dopaminergic neurons present in the SNpc possess a fundamental function in the regulation of sleep processes, particularly in promoting REM sleep. en
dc.description.sponsorship AFIP
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 7
dc.language.iso eng
dc.publisher Public Library Science
dc.relation.ispartof Plos One
dc.rights Acesso aberto
dc.title The Role of the Substantia Nigra Pars Compacta in Regulating Sleep Patterns in Rats en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Fed Parana
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliation Univ Fed Parana, Dept Farmacol, BR-80060000 Curitiba, Parana, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 98/14.303-3
dc.identifier.file WOS000207451500022.pdf
dc.identifier.doi 10.1371/journal.pone.0000513
dc.description.source Web of Science
dc.identifier.wos WOS:000207451500022


Name: WOS000207451500022.pdf
Size: 345.6Kb
Format: PDF
Open file

This item appears in the following Collection(s)

Show simple item record




My Account