In71, an Enterobacter cloacae bla(VIM-1)-carrying integron related to In70.2 from Italian Pseudomonas aeruginosa isolates: A SENTRY antimicrobial surveillance program report

In71, an Enterobacter cloacae bla(VIM-1)-carrying integron related to In70.2 from Italian Pseudomonas aeruginosa isolates: A SENTRY antimicrobial surveillance program report

Author Castanheira, Mariana Google Scholar
Sader, Helio S. Google Scholar
Jones, Ronald N. Google Scholar
Debbia, Eugenio Google Scholar
Picao, Renata C. Google Scholar
Gales, Ana C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
JMI Labs
San Martino Inst Microbiol
Abstract An Enterobacter cloacae strain showing decreased susceptibility to carbapenems was isolated from a blood culture of a patient hospitalized in Genoa, Italy, and screened for the presence of metallo-beta-lactamase (MBL) genes as part of the SENTRY Antimicrobial Surveillance Program. A bla(VIM-1)-carrying integron named In71 nearly identical to In70.2 reported in Pseudomonas aeruginosa strains isolated from various Italian cities since 2001 was identified in this strain. Interestingly, the In71 did not carry aadA1 nor possess the ISPa7 usually found in the P. aeruginosa integron In70.2. Mobilization of MBL genes from P. aeruginosa to members of the Enterobacteriaceae family is very worrisome because the rapid and wide dissemination of these potent antimicrobial resistance mechanisms could jeopardize the clinical use of carbapenems for the treatment of multidrug-resistant Enterobacteriaceae infections.
Language English
Date 2007-06-01
Published in Microbial Drug Resistance-mechanisms Epidemiology and Disease. New Rochelle: Mary Ann Liebert Inc, v. 13, n. 2, p. 130-134, 2007.
ISSN 1076-6294 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert Inc
Extent 130-134
Origin http://dx.doi.org/10.1089/mdr.2007.728
Access rights Closed access
Type Article
Web of Science ID WOS:000248363200010
URI http://repositorio.unifesp.br/handle/11600/29809

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