Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats

Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats

Autor Leite, Aline de Lima Google Scholar
Santiago, Joel Ferreira Google Scholar
Levy, Flavia Mauad Google Scholar
Maria, Andrea Gutierrez Google Scholar
Fernandes, Mileni da Silva Google Scholar
Favero Salvadori, Daisy Maria Google Scholar
Ribeiro, Daniel Araki Google Scholar
Rabelo Buzalaf, Marflia Afonso Google Scholar
Instituição Universidade de São Paulo (USP)
Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Resumo Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been some speculation that excess fluoride could cause an impact on genome integrity. in the current study, the potential DNA damage associated with exposure to fluoride was assessed in cells of blood, liver, kidney, thyroid gland and urinary bladder by the single cell gel (comet) assay. Male Wistar rats aging 75 days were distributed into seven groups: Groups 1 (control), 2, 3, 4, 5, 6 and 7 received 0 (deionized water), 10, 20, 40, 60, 80 and 100 mgF/Kg body weight from sodium fluoride (NaF), respectively, by gastrogavage. These groups were killed at 2 h after the administration of the fluoride doses. the level of DNA strand breaks did not increase in all organs evaluated and at all doses of NaF tested, as depicted by the mean tail moment. Taken together, our results suggest that oral exposure to NaF did not result in systemic genotoxic effect in multiple organs related to fluoride toxicity. Since DNA damage is an important step in events leading to carcinogenesis, this study represents a relevant contribution to the correct evaluation of the potential health risk associated with chemical exposure.
Assunto acute exposure
comet assay
DNA damage
fluoride
rats
Idioma Inglês
Data 2007-05-01
Publicado em Human & Experimental Toxicology. London: Sage Publications Ltd, v. 26, n. 5, p. 435-440, 2007.
ISSN 0960-3271 (Sherpa/Romeo, fator de impacto)
Editor Sage Publications Ltd
Extensão 435-440
Fonte http://dx.doi.org/10.1177/0960327107076288
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000248156000006
URI http://repositorio.unifesp.br/handle/11600/29743

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