Up-regulation of cyclooxygenase-2 in different grades of acute human renal allograft rejection

Show simple item record

dc.contributor.author Rangel, Erika B.
dc.contributor.author Moura, Luiz A.
dc.contributor.author Franco, Marcello F.
dc.contributor.author Pacheco-Silva, Alvaro
dc.date.accessioned 2016-01-24T12:42:02Z
dc.date.available 2016-01-24T12:42:02Z
dc.date.issued 2007-04-01
dc.identifier http://dx.doi.org/10.1016/j.plefa.2007.01.005
dc.identifier.citation Prostaglandins Leukotrienes and Essential Fatty Acids. Edinburgh: Churchill Livingstone, v. 76, n. 4, p. 235-243, 2007.
dc.identifier.issn 0952-3278
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29633
dc.description.abstract Background: Cyclooxygenase-2 (COX-2) is up-regulated by a variety of stimuli that are associated with tissue injury and inflammation.Methods: the purpose of this study was to analyze COX-2 detection during different grades of acute human renal allograft rejection. COX-2 expressions were analyzed by immunohistochemistry in 74 samples obtained from biopsies with acute rejection of different grades (n = 48), tubular changes (n = 13) and from kidney allografts with stable function (n = 13).Results: in interstitial area, there was a significant correlation of COX-2 induction in acute rejection in comparison to tubular changes (1.67 vs. 0.76, p = 0.02) and stable function (vs. 0.07, p < 0.001), as well as in vessels in the group with acute rejection in relation to stable function (1.1 vs. 0, p = 0.04). When the group with acute rejection was analyzed in subgroups, there was a clear increase of COX-2 expression from acute rejection grade 1B to III in vessels, in inflammatory infiltrating cells in interstitial area and in glomeruli, while borderline and IA grades were intermediate.Conclusion: COX-2 is up-regulated during acute human renal allograft rejection according to the severity of acute rejection and could be used as a marker of inflammation in kidney transplantation. (c) 2007 Elsevier B.V. All rights reserved. en
dc.format.extent 235-243
dc.language.iso eng
dc.publisher Churchill Livingstone
dc.relation.ispartof Prostaglandins Leukotrienes and Essential Fatty Acids
dc.rights Acesso restrito
dc.title Up-regulation of cyclooxygenase-2 in different grades of acute human renal allograft rejection en
dc.type Artigo
dc.contributor.institution Hosp Rim & Hipertensao
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Hosp Rim & Hipertensao, Div Nephrol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Hosp Rim & Hipertensao, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1016/j.plefa.2007.01.005
dc.description.source Web of Science
dc.identifier.wos WOS:000246515100005



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account