Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats

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dc.contributor.author Rudnicki, M.
dc.contributor.author Silveira, M. M.
dc.contributor.author Pereira, T. V.
dc.contributor.author Oliveira, M. R.
dc.contributor.author Reginatto, F. H.
dc.contributor.author Dal-Pizzol, F.
dc.contributor.author Moreira, J. C. F.
dc.date.accessioned 2016-01-24T12:42:02Z
dc.date.available 2016-01-24T12:42:02Z
dc.date.issued 2007-04-01
dc.identifier http://dx.doi.org/10.1016/j.fct.2006.10.022
dc.identifier.citation Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 45, n. 4, p. 656-661, 2007.
dc.identifier.issn 0278-6915
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29628
dc.description.abstract The leaf extract of Passiflora alata Dryander (P. alata) has been demonstrated to possess antioxidant activity in vitro. the aim of this study was to investigate the effects of P. alata leaf extract pretreatment on carbon tetrachloride-treated rats. Male Wistar rats were randomly allocated into four groups: group 1 (control - vehicle), group 2 and 3 (P. alata extract - 1 and 5 mg/kg, respectively) and group 4 (trolox - 0.18 mg/kg). Rats received daily pretreatment by oral gavage for 30 days followed by a single dose of CCl4 (3 ml/kg i.p. in vegetable oil) on the 30th day and were killed after 6 h. the pretreatment with the P. alata extract provided significant protection to liver, evidenced by lower degree of necrosis, decreased lipid peroxidation (TBARS) and higher catalase and superoxide dismutase activities. Additionally, pretreated-rats with P. alata (5 mg/kg) showed significantly decreased cardiac TBARS levels. Our results indicate that a low oral dose of P. alata leaf extract has both hepato and cardioprotective effects on rats treated with CCl4. (c) 2006 Elsevier B.V. All rights reserved. en
dc.format.extent 656-661
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Food and Chemical Toxicology
dc.rights Acesso restrito
dc.subject Passiflora alata en
dc.subject antioxidant en
dc.subject carbon tetrachloride en
dc.title Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Univ Fed Rio Grande do Sul
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Sul Catarinense
dc.description.affiliation Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Ctr Estudos Estresse Oxidat, Porto Alegre, RS, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Curso Farm, Inst Ciencias Biol, São Paulo, Brazil
dc.description.affiliation Univ Sul Catarinense, Lab Fisiopatol Expt, Criciuma, SC, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Curso Farm, Inst Ciencias Biol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.fet.2006.10.022
dc.description.source Web of Science
dc.identifier.wos WOS:000245758000018



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