Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats

Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats

Author Rudnicki, M. Google Scholar
Silveira, M. M. Google Scholar
Pereira, T. V. Google Scholar
Oliveira, M. R. Google Scholar
Reginatto, F. H. Google Scholar
Dal-Pizzol, F. Google Scholar
Moreira, J. C. F. Google Scholar
Institution Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Univ Sul Catarinense
Abstract The leaf extract of Passiflora alata Dryander (P. alata) has been demonstrated to possess antioxidant activity in vitro. the aim of this study was to investigate the effects of P. alata leaf extract pretreatment on carbon tetrachloride-treated rats. Male Wistar rats were randomly allocated into four groups: group 1 (control - vehicle), group 2 and 3 (P. alata extract - 1 and 5 mg/kg, respectively) and group 4 (trolox - 0.18 mg/kg). Rats received daily pretreatment by oral gavage for 30 days followed by a single dose of CCl4 (3 ml/kg i.p. in vegetable oil) on the 30th day and were killed after 6 h. the pretreatment with the P. alata extract provided significant protection to liver, evidenced by lower degree of necrosis, decreased lipid peroxidation (TBARS) and higher catalase and superoxide dismutase activities. Additionally, pretreated-rats with P. alata (5 mg/kg) showed significantly decreased cardiac TBARS levels. Our results indicate that a low oral dose of P. alata leaf extract has both hepato and cardioprotective effects on rats treated with CCl4. (c) 2006 Elsevier B.V. All rights reserved.
Keywords Passiflora alata
antioxidant
carbon tetrachloride
Language English
Date 2007-04-01
Published in Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 45, n. 4, p. 656-661, 2007.
ISSN 0278-6915 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 656-661
Origin http://dx.doi.org/10.1016/j.fct.2006.10.022
Access rights Closed access
Type Article
Web of Science ID WOS:000245758000018
URI http://repositorio.unifesp.br/handle/11600/29628

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