Cocaine-induced genital reflexes in paradoxical sleep deprived rats: Indications of mediation by serotonin receptors

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dc.contributor.author Andersen, Monica L.
dc.contributor.author Antunes, Isabela B.
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:59Z
dc.date.available 2016-01-24T12:41:59Z
dc.date.issued 2007-03-30
dc.identifier http://dx.doi.org/10.1016/j.pnpbp.2006.11.018
dc.identifier.citation Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 31, n. 2, p. 496-502, 2007.
dc.identifier.issn 0278-5846
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29596
dc.description.abstract As paradoxical sleep deprivation (PSD) modifies cocaine-induced genital reflexes (penile erection [PE] and ejaculation [EJ]) and since cocaine is a scrotonin (5-HT) reuptake inhibitor, we hypothesized that 5-HT also plays a role in these genital reflexes in PSD male rats. After a 4-day period of PSD each group was administered with serotonergic, drugs prior to cocaine and placed in observation cages. the selective 5-HT1 agonist (8-OH-DPAT) completely abolished PE events whereas the antagonist (pindolol) did not produce significant effects in the number of animals displaying PE. It was found that both drugs reduce the frequency of PE. There were no significant effects on the number of animals that ejaculated or in its frequency after pindolol although both parameters were reduced by the agonist at the highest doses (2 and 4 mg/kg, SC). Pretreatment with the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (0.12; 0.5 and 1 mg/kg, SC) significantly reduced the number of rats displaying PE and all doses reduced both PE and EJ frequencies. the number of animals displaying PE after 5-HT2 antagonist (ketanserin) pretreatment at 1 and 2.5 mg/kg doses was significantly decreased in relation to vehicle rats and all doses reduced PE frequency. 5-HT2 compounds at any dose did not affect the number of animals ejaculating, but the frequency was significantly reduced by all doses of DOI and by 1 to 5 mg/kg doses of ketanserin. Taken together, the results suggest that serotonergic receptors play an important role in genital reflexes induced by cocaine in sleep deprived males. (c) 2006 Elsevier Inc. All rights reserved. en
dc.format.extent 496-502
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Progress in Neuro-psychopharmacology & Biological Psychiatry
dc.rights Acesso restrito
dc.subject cocaine en
dc.subject DOI en
dc.subject DPAT en
dc.subject ketanserin en
dc.subject pindolol en
dc.subject serotonin receptors en
dc.subject sexual behavior en
dc.subject sleep deprivation en
dc.title Cocaine-induced genital reflexes in paradoxical sleep deprived rats: Indications of mediation by serotonin receptors en
dc.type Resenha
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1016/j.pnpbp.2006.11.018
dc.description.source Web of Science
dc.identifier.wos WOS:000244808800029



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