Effects of buprenorphine on nociception and spontaneous locomotor activity in horses

Effects of buprenorphine on nociception and spontaneous locomotor activity in horses

Author Carregaro, Adriano B. Google Scholar
Luna, Stelio P. L. Google Scholar
Mataqueiro, Maria Isabel Google Scholar
Queiroz-Neto, Antonio de Google Scholar
Institution Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective-To investigate spontaneous locomotor activity (SLA) and antinociceptive effects of buprenorphine in horses.Animals-6 healthy adult horses.Procedures-Horses received each of 3 treatments (10 mL of saline [0.9% NaCl] solution, 5 mu g of buprenorphine/kg, or 10 mu g of buprenorphine/kg). Treatments were administered IV Order of treatments was randomized, and there was a 10-day interval between subsequent treatments. Spontaneous locomotor activity was investigated in a behavioral box by use of infrared photoelectric sensors connected to a computer, which detected movement of each horse. Antinociceptive effect was investigated by hoof-withdrawal reflex latency (HWRL) and skin-twitching reflex latency (STBL) after painful stimulation with a heat lamp.Results-Moderate excitement was observed in all horses from 5 to 10 minutes after the administration of both dosages of buprenorphine. the SLA increased significantly for 6 and 14 hours after IV administration of 5 and 10 mu g of buprenorphine/kg, respectively. Values for HWRL increased significantly only at 30 minutes after injection of 5 mu g of buprenorphine/kg, whereas STRL and HWRL each increased significantly from 1 to 6 hours (except at 2 and 4 hours) and 11 hours, respectively, after injection of 10 mu g of buprenorphine/kg.Conclusions and Clinical Relevance-IV injection of buprenorphine caused a dose-dependent increase in SLA, but only the dose of 10 mu g/kg induced analgesia on the basis of results for the experimental method used.
Language English
Date 2007-03-01
Published in American Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 68, n. 3, p. 246-250, 2007.
ISSN 0002-9645 (Sherpa/Romeo, impact factor)
Publisher Amer Veterinary Medical Assoc
Extent 246-250
Origin http://dx.doi.org/10.2460/ajvr.68.3.246
Access rights Closed access
Type Article
Web of Science ID WOS:000244625700005
URI http://repositorio.unifesp.br/handle/11600/29586

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