Leptin deficiency leads to the regulation of kinin receptors expression in mice

Leptin deficiency leads to the regulation of kinin receptors expression in mice

Autor Abe, Karina Camasmie Google Scholar
Silva Mori, Marcelo Alves da Google Scholar
Pesquero, Joao Bosco Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Kinins are vasoactive and pro-inflammatory peptides generated by the cleavage of the kininogen by kallikreins. Two kinin receptors have been described and denominated B1 and B2. Obesity frequently accompanies other pathologies, such as diabetes and hypertention. the clustering of these pathologies is usually known as metabolic syndrome. Mice lacking leptin gene (ob/ob) are severely obese and hyperphagic. Using quantitative RT-PCR analysis of B1 and B2 mRNAs expression, we described for the first time a correlation between the kallikrein-kinin system (KKS) and severe obesity in mice. the ob/ob mice presented lower expression of 132 mRNA in the white adipose tissue (WAT) and hypothalamus, both primary sites for neuroendocrine regulation of the energetic metabolism. 131 mRNA, however, is overexpressed in these tissues of ob/ob mice. An upregulation of the B I mRNA has also been seen in liver, abdominal aorta and stomach fundus. However, different from the lean mice, the expression of the B I mRNA in brown adipose tissue (BAT) and heart is completely abolished. Our data show that kinin receptors are differently modulated in distinct tissues in obesity. These findings suggest a connection between the KKS and obesity, and suggest that kinin receptors could be involved in the ethiopathogenesis of the metabolic syndrome. (c) 2006 Elsevier B.V. All rights reserved.
Assunto obesity
ob/ob mice
kallikrein-kinin system
kinin receptors
Idioma Inglês
Data 2007-02-01
Publicado em Regulatory Peptides. Amsterdam: Elsevier B.V., v. 138, n. 2-3, p. 56-58, 2007.
ISSN 0167-0115 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 56-58
Fonte http://dx.doi.org/10.1016/j.regpep.2006.11.018
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000244012400002
URI http://repositorio.unifesp.br/handle/11600/29497

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