A step test to assess exercise-related oxygen desaturation in interstitial lung disease

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dc.contributor.author Dal Corso, Simone [UNIFESP]
dc.contributor.author Duarte, Sandra Reis [UNIFESP]
dc.contributor.author Neder, Jose Alberto [UNIFESP]
dc.contributor.author Malaguti, Carla [UNIFESP]
dc.contributor.author Fuccio, Marcelo Bicalho de [UNIFESP]
dc.contributor.author Pereira, Carlos Alberto de Castro [UNIFESP]
dc.contributor.author Nery, Luiz Eduardo [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:51Z
dc.date.available 2016-01-24T12:41:51Z
dc.date.issued 2007-02-01
dc.identifier http://dx.doi.org/10.1183/09031936.00094006
dc.identifier.citation European Respiratory Journal. Sheffield: European Respiratory Soc Journals Ltd, v. 29, n. 2, p. 330-336, 2007.
dc.identifier.issn 0903-1936
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29480
dc.description.abstract A 6-min step test (6MST) may constitute a practical method for routinely assessing effort tolerance and exercise-related oxyhaemoglobin desaturation (ERD) in the primary care of patients with interstitial lung disease.In total, 31 patients (19 males) with idiopathic pulmonary fibrosis I and chronic hypersensitivity pneumonia were submitted, on different days, to two 6MSTs. Physiological responses were compared with those found on maximal and submaximal cycle ergometer tests at the same oxygen uptake I Chronic breathlessness was also determined, as measured by the baseline dyspnoea index (BDI).Responses to 6MST were highly reproducible: 1.3 +/- 2.0 steps(.)min(-1), +/- 5 beats(.)min(-1) (cardiac frequency), +/- 50 mL(.)min(-1) (V'O-2), +/- 7 L(.)min(-1) (minute ventilation) and +/- 2% (arterial oxygen saturation measured by pulse oximetry (Sp,O-2)). the number of steps climbed in 6 min was correlated to peak V'O-2 and the BDI. There were significant associations among the tests in relation to presence (change in Sp,O-2 between rest and exercise >= 4%) and severity (Sp,O-2 < 88%) of ERD. Four patients, however, presented ERD only in response to 6MST. Resting diffusing capacity of the lung for carbon monoxide and alveolar-arterial oxygen tension difference were the independent predictors of the number of steps climbed.A single-stage, self-paced 6-min step test provided reliable and reproducible estimates of exercise capacity and exercise-related oxyhaemoglobin desaturation in interstitial lung disease patients. en
dc.format.extent 330-336
dc.language.iso eng
dc.publisher European Respiratory Soc Journals Ltd
dc.relation.ispartof European Respiratory Journal
dc.rights Acesso aberto
dc.subject exercise induced en
dc.subject exercise tests en
dc.subject interstitial lung diseases en
dc.subject oxygen saturation en
dc.subject oxygen uptake en
dc.subject pulmonary dysfunction en
dc.title A step test to assess exercise-related oxygen desaturation in interstitial lung disease en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIFESP, EPM, Dept Med,SEFICE, Div Resp,Pulm Funct & Clin Exercise Physiol Unit, BR-04020050 São Paulo, Brazil
dc.description.affiliationUnifesp UNIFESP, EPM, Dept Med,SEFICE, Div Resp,Pulm Funct & Clin Exercise Physiol Unit, BR-04020050 São Paulo, Brazil
dc.identifier.doi 10.1183/09031936.00094006
dc.description.source Web of Science
dc.identifier.wos WOS:000244283900019



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