A step test to assess exercise-related oxygen desaturation in interstitial lung disease

A step test to assess exercise-related oxygen desaturation in interstitial lung disease

Author Dal Corso, Simone Autor UNIFESP Google Scholar
Duarte, Sandra Reis Autor UNIFESP Google Scholar
Neder, Jose Alberto Autor UNIFESP Google Scholar
Malaguti, Carla Autor UNIFESP Google Scholar
Fuccio, Marcelo Bicalho de Autor UNIFESP Google Scholar
Pereira, Carlos Alberto de Castro Autor UNIFESP Google Scholar
Nery, Luiz Eduardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract A 6-min step test (6MST) may constitute a practical method for routinely assessing effort tolerance and exercise-related oxyhaemoglobin desaturation (ERD) in the primary care of patients with interstitial lung disease.In total, 31 patients (19 males) with idiopathic pulmonary fibrosis I and chronic hypersensitivity pneumonia were submitted, on different days, to two 6MSTs. Physiological responses were compared with those found on maximal and submaximal cycle ergometer tests at the same oxygen uptake I Chronic breathlessness was also determined, as measured by the baseline dyspnoea index (BDI).Responses to 6MST were highly reproducible: 1.3 +/- 2.0 steps(.)min(-1), +/- 5 beats(.)min(-1) (cardiac frequency), +/- 50 mL(.)min(-1) (V'O-2), +/- 7 L(.)min(-1) (minute ventilation) and +/- 2% (arterial oxygen saturation measured by pulse oximetry (Sp,O-2)). the number of steps climbed in 6 min was correlated to peak V'O-2 and the BDI. There were significant associations among the tests in relation to presence (change in Sp,O-2 between rest and exercise >= 4%) and severity (Sp,O-2 < 88%) of ERD. Four patients, however, presented ERD only in response to 6MST. Resting diffusing capacity of the lung for carbon monoxide and alveolar-arterial oxygen tension difference were the independent predictors of the number of steps climbed.A single-stage, self-paced 6-min step test provided reliable and reproducible estimates of exercise capacity and exercise-related oxyhaemoglobin desaturation in interstitial lung disease patients.
Keywords exercise induced
exercise tests
interstitial lung diseases
oxygen saturation
oxygen uptake
pulmonary dysfunction
Language English
Date 2007-02-01
Published in European Respiratory Journal. Sheffield: European Respiratory Soc Journals Ltd, v. 29, n. 2, p. 330-336, 2007.
ISSN 0903-1936 (Sherpa/Romeo, impact factor)
Publisher European Respiratory Soc Journals Ltd
Extent 330-336
Origin http://dx.doi.org/10.1183/09031936.00094006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000244283900019
URI http://repositorio.unifesp.br/handle/11600/29480

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