Genetic polymorphisms of cytochrome P450c17 alpha (CYP17) and progesterone receptor genes (PROGINS) in the assessment of endometriosis risk

Genetic polymorphisms of cytochrome P450c17 alpha (CYP17) and progesterone receptor genes (PROGINS) in the assessment of endometriosis risk

Author Carvalho, Cristina Valletta de Autor UNIFESP Google Scholar
Nogueira-de-Souza, Naiara Corrêa Autor UNIFESP Google Scholar
Costa, Ana Maria Massad Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Girão, Manoel João Batista Autor UNIFESP Google Scholar
D'Amora, Paulo Autor UNIFESP Google Scholar
Schor, Eduardo Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We designed the present study in order to evaluate the eventual role of polymorphisms in the genes encoding cytochrome P450c17 alpha (CYP17) and the progesterone receptor (PROGINS) as risk factors for endometriosis development. Eligible cases consisted of 121 women with surgically confirmed endometriosis who underwent treatment in a hospital in São Paulo, Brazil during the period from September 2003 to September 2005. the 281 controls were participants with normal gynecological as well as pelvic ultrasound evaluation, who did not have any gynecological conditions during their reproductive lives such as pelvic pain and/or dyspareunia nor infertility history. Genomic DNA was obtained from buccal cells and processed for DNA extraction using the GFX DNA extraction kit (GE Healthcare). the CYP17 (- 34T-->C) polymerase chain reaction-restriction fragment length polymorphism assay has been described previously, as has the progesterone receptor polymorphism (PROGINS) detection assay. PROGINS heterozygosis genotype frequencies were shown to be statistically higher in endometriosis cases compared with controls. On the other hand, differences in the CYP17 polymorphism (- 34T --> C) frequencies were not even close to significance (p = 0.278) according to our findings.
Keywords endometriosis
CYP17
progesterone receptor
polymorphism
Language English
Date 2007-01-01
Published in Gynecological Endocrinology. Lancaster: Parthenon Publishing Group, v. 23, n. 1, p. 29-33, 2007.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Parthenon Publishing Group
Extent 29-33
Origin http://dx.doi.org/10.1080/09513590601024707
Access rights Closed access
Type Article
Web of Science ID WOS:000244100200005
URI http://repositorio.unifesp.br/handle/11600/29404

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