Transcutaneous electrical nerve stimulation in viability of a random skin flap in nicotine-treated rats

Transcutaneous electrical nerve stimulation in viability of a random skin flap in nicotine-treated rats

Author Abrantes Russo, Claudia Regina Google Scholar
Leite, Mauro Teixeira Google Scholar
Gomes, Heitor Carvalho Google Scholar
Ferreira, Lydia Masako Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Skin flaps are extensively used in plastic surgery, the main postoperative problems being ischemia and necrosis. Nicotine has acute vasoconstrictive properties, diminishing blood flow and increasing the risk of flap necrosis. Transcutaneous electrical nerve stimulation (TENS) was effective in reducing necrosis in random skin flaps in rats. Therefore, the authors decided to test the efficacy of TENS to reduce necrosis in the presence of nicotine.Methods: Sixteen adult male Wistar-Escola Paulista de Medicina (EPM) rats were distributed, at random, in 2 groups of 8 animals. the nicotine group (NG) received this drug subcutaneously (1.2 mg/kg/d), for 1 week before flap elevation. the nicotine plus TENS group (NTG) followed the same routine. Immediately after the operative procedure and on the next 2 postoperative days, the treatment group (NTG) was submitted to TENS during an hour under anesthesia. NG animals were sham exposed. After 7 days, the percentages of necrosis were determined.Results: the NG had a mean value of 45% and the NTG, 21% of necrosis, a difference statistically significant (P < 0.001).Conclusion: TENS was effective in the reduction of necrosis in this flap model.
Keywords random flaps
nicotine
TENS
rats
Language English
Date 2006-12-01
Published in Annals of Plastic Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 57, n. 6, p. 670-672, 2006.
ISSN 0148-7043 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 670-672
Origin http://dx.doi.org/10.1097/01.sap.0000235503.74038.a9
Access rights Closed access
Type Article
Web of Science ID WOS:000242318800017
URI http://repositorio.unifesp.br/handle/11600/29307

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