Autoantibodies directed to extracellular matrix components in patients with different clinical forms of periodontitis

Autoantibodies directed to extracellular matrix components in patients with different clinical forms of periodontitis

Author De-Gennaro, Luiz A. Google Scholar
Lopes, Jose D. Google Scholar
Mariano, Mario Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Periodontal disease occurs in different clinical forms, from mild and easily controllable to more aggressive inflammatory manifestations, with difficult clinical or surgical control. There is evidence that a local autoimmune reaction may participate in the onset and persistence of the aggressive forms of periodontal disease. As the underlying mechanism in this process is not fully understood, we decided to investigate whether patients bearing this form of disease presented higher levels of antibodies directed to extracellular matrix (ECM) components such as type I collagen, fibronectin, and laminin.Methods: Three groups of patients were selected by clinical criteria: 22 subjects with aggressive periodontitis (AgP) = group A; 18 subjects with chronic periodontitis (CP) = group B; and 10 healthy (H) volunteers without periodontal disease = group C. Autoantibody levels were evaluated in the sera of these patients using the enzyme-linked immunosorbent assay (ELISA) method.Results: the levels of autoantibodies directed to ECM components (type I collagen, fibronectin and laminin) in the sera of patients with AgP and CP were shown to be statistically different (P < 0.05).Conclusions: Although the present findings suggest an involvement of autoantibodies directed to ECM components per se in the pathogeny of certain types of periodontal disease, the available data do not support the classification of the lesions as autoimmune. Nevertheless, the findings open a possibility for the development of an additional method for a differential diagnosis of the aggressive forms of periodontal disease.
Keywords autoantibodies
extracellular matrix
fibronectin
laminin
type I collagen
Language English
Date 2006-12-01
Published in Journal of Periodontology. Chicago: Amer Acad Periodontology, v. 77, n. 12, p. 2025-2030, 2006.
ISSN 0022-3492 (Sherpa/Romeo, impact factor)
Publisher Amer Acad Periodontology
Extent 2025-2030
Origin http://dx.doi.org/10.1902/jop.2006.060104
Access rights Closed access
Type Article
Web of Science ID WOS:000243801300012
URI http://repositorio.unifesp.br/handle/11600/29305

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