Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease

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dc.contributor.author Iores-Marcal, Ligia M. [UNIFESP]
dc.contributor.author Viel, Tania A.
dc.contributor.author Buck, Hudson Sousa
dc.contributor.author Nunes, Viviane A. [UNIFESP]
dc.contributor.author Gozzo, Andrezza Justino [UNIFESP]
dc.contributor.author Cruz-Silva, Ilana [UNIFESP]
dc.contributor.author Miranda, Antonio [UNIFESP]
dc.contributor.author Shimamoto, Kazuaki
dc.contributor.author Ura, Nobuyuki
dc.contributor.author Araujo, Mariana S. [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:38Z
dc.date.available 2016-01-24T12:41:38Z
dc.date.issued 2006-12-01
dc.identifier http://dx.doi.org/10.1016/j.peptides.2006.08.012
dc.identifier.citation Peptides. New York: Elsevier B.V., v. 27, n. 12, p. 3363-3369, 2006.
dc.identifier.issn 0196-9781
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29299
dc.description.abstract The kallikrein-kinin system is involved in a variety of physiological and pathological processes. Components of this system, identified in rat and human brains, can be altered in neurodegenerative processes such as Alzheimer's disease. Here, we studied kinin release and its inactivation in rats submitted to chronic cerebroventricular infusion of beta-amyloid (A beta) peptide. Neurodegeneration was confirmed by histological analysis of brain samples. in cerebrospinal fluid of animals infused with A beta, bradykinin concentration was increased, as determined by radioimmunoassay. However, in the brain of A beta group, we only detected the tripeptide Arg-Pro-Pro, purified by reversed-phase chromatography and characterized by liquid chromatography-electrospray ionization mass spectrometry. This fragment of bradykinin indicated the possible participation of kinin-processing enzymes in the brain such as a prolyl oligopeptidase. (c) 2006 Elsevier Inc. All rights reserved. en
dc.format.extent 3363-3369
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Peptides
dc.rights Acesso restrito
dc.subject beta-amyloid en
dc.subject bradykinin en
dc.subject kallikrein-kinin system en
dc.subject kininase en
dc.title Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Fac Ciencias Med Santa Casa São Paulo
dc.contributor.institution Sapporo Med Univ
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Biochem, BR-04044020 São Paulo, SP, Brazil
dc.description.affiliation Fac Ciencias Med Santa Casa São Paulo, Dept Physiol, São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04044020 São Paulo, SP, Brazil
dc.description.affiliation Sapporo Med Univ, Dept Internal Med 2, Sapporo, Hokkaido, Japan
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Biochem, BR-04044020 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04044020 São Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.peptides.2006.08.012
dc.description.source Web of Science
dc.identifier.wos WOS:000242821300042



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