Scaling skeletal muscle function to mass in patients with moderate-to-severe COPD

Scaling skeletal muscle function to mass in patients with moderate-to-severe COPD

Autor Malaguti, Carla Google Scholar
Nery, Luiz E. Google Scholar
Dal Corso, Simone Google Scholar
Napolis, Lara Google Scholar
De Fuccio, Marcelo Bicalho Google Scholar
Lazaretti-Castro, Marise Autor UNIFESP Google Scholar
Neder, José Alberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Skeletal muscle performance and muscle mass are commonly reduced in patients with advanced chronic obstructive pulmonary disease (COPD). It is currently unclear, however, whether negative changes in muscle structure and function are proportionately related to each other in these patients. in a cross-sectional study, 39 patients (post-bronchodilator FEV1 = 49.7 +/- 15.5% pred) and 17 controls were submitted to knee isokinetic dynamometry [peak torque (PT), isometric strength (IS), and total work (TW)] and dual energy X-ray absorptiometry for the evaluation of leg muscle mass (LMM). Muscle function (F) was normalised for LMM by using ratio standards (F center dot LMM-1), power function ratios (F center dot LMM-b, where b is usually not equal 1), and analysis of covariance (ANCOVA). Patients with COPD presented with reduced PT, IS, TW, and LMM as compared to controls: there were significant linear correlations among these variables in both groups (P < 0.05). Ratio standards of PT center dot LMM-1 and TW center dot LMM-1 were, on average, 14% lower in patients than controls (P < 0.01). the coefficients for allometric correction of IS and TW were significantly higher in patients as compared to controls (0.975 vs. 0.603 and 1.471 vs. 0.824, respectively, P < 0.05), i.e. more LMM was needed to generate a given functional output in patients than normal subjects. in addition, adjusted means of muscle function variables by ANCOVA were 11-18% lower for patients than controls with LMM as the covariate (P < 0.05). We conclude that factors other than simple atrophy (i.e. mass-independent mechanisms) might play a role in explaining the COPD-related skeletal muscle dysfunction.
Assunto muscle
oxygen consumption
Idioma Inglês
Data 2006-11-01
Publicado em European Journal of Applied Physiology. New York: Springer, v. 98, n. 5, p. 482-488, 2006.
ISSN 1439-6319 (Sherpa/Romeo, fator de impacto)
Editor Springer
Extensão 482-488
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000242658400006

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