Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus

Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus

Autor Palma, Beatriz Duarte Google Scholar
Gabriel, Alexandre Google Scholar
Colugnati, Fernando A. B. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol 291: R1527-R1532, 2006. First published June 29, 2006; doi: 10.1152/ajpregu.00186.2006.-Sleep is hypothesized to play a restorative role on immune system. in addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F-1 mice develop an autoimmune disease that strongly resembles SLE in humans, exhibiting high titers of antinuclear antibodies associated with the development of rapidly progressive and lethal glomerulonephritis. On the basis of this evidence, the present study examined the onset and progress of lupus in as-yet healthy female mice submitted to sleep deprivation. Sleep deprivation was accomplished by two 96-h periods in the multiple-platform method when mice were 10 wk old, and they were observed until 28 wk of age. Blood samples were collected from the orbital plexus fortnightly to evaluate serum antinuclear antibodies and anti-double-stranded DNA. Proteinuria and longevity as well as body weight were also assessed. the results indicated that mice submitted to sleep deprivation exhibited an earlier onset of the disease, as reflected by the increased number of antinuclear antibodies. However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease.
Palavra-chave sleep
New Zealand Black/New Zealand White F-1 mice
antinuclear antibody
Idioma Inglês
Data de publicação 2006-11-01
Publicado em American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 291, n. 5, p. R1527-R1532, 2006.
ISSN 0363-6119 (Sherpa/Romeo, fator de impacto)
Publicador Amer Physiological Soc
Extensão R1527-R1532
Fonte http://dx.doi.org/10.1152/ajpregu.00186.2006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000241106400040
Endereço permanente http://repositorio.unifesp.br/handle/11600/29221

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