A proposed score for predicting severe infection complications in children with chemotherapy-induced febrile neutropenia

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dc.contributor.author Porto Rondinelli, Patricia Imperatriz
dc.contributor.author Braga Ribeiro, Karina de Cassia
dc.contributor.author Camargo, Beatriz de
dc.date.accessioned 2016-01-24T12:41:31Z
dc.date.available 2016-01-24T12:41:31Z
dc.date.issued 2006-10-01
dc.identifier http://dx.doi.org/10.1097/01.mph.0000212996.94929.0b
dc.identifier.citation Journal of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 28, n. 10, p. 665-670, 2006.
dc.identifier.issn 1077-4114
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29198
dc.description.abstract Background: Febrile neutropenia (FN) is one of most common complications in patients with cancer during chemotherapy. Identifying factors associated with severe infectious complications (SICs) at time of admission for fever and neutropenia is necessary for better treatment.Procedure: We revised all medical charts of patients under 18 years old who developed a first episode of FN present from January 2000 to December 2003. Criteria for a SIC were defined. These included the presence of bacteremia or fungemia, sepsis, septic shock, and/or death from infection. To identify risk factors SIC was associated with the first FN episode.Results: Factors identified in univariate analysis were female sex, age less than 5 years old, acute myeloid leukemia, baseline disease activity, use of central venous catheter, hemoglobin level < 7 g/dL, leukocytes count < 500cellS/mm(3), granulocytes count < 500 cells/mm(3), monocytes count < 100 cells/mm(3), platelets < 20,000, and body temperature > 38.5 degrees C, a chemotherapy interval < 7 days, presence of mucositis, pneumonia, absence of upper respiratory tract infection, or the presence of any clinical focus on first physical examination. in multivariate analysis the variables that remained as independent predictive risk factors for SIC were age less than 5 years, use of central venous catheter, body temperature > 38.5 degrees C, hemoglobin level < 7 g/dL, any clinical focus of infection on first examination and absence of upper respiratory tract infection. the FN population was than divided among 3 different risk groups as follows: group I (low risk), group 2 (intermediate risk), with a 13 (4.4 to 38.3)-fold risk for SIC; and group 3 (high risk) with a 50 (16.4 to 149.2)-fold risk for SIC.Conclusions: This study suggests that patients with FN can be stratified for risk of SIC using clinical parameters at hospital admission. en
dc.format.extent 665-670
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Journal of Pediatric Hematology Oncology
dc.rights Acesso restrito
dc.subject infection en
dc.subject febrile neutropenia en
dc.subject children with cancer en
dc.subject severe infection complications en
dc.title A proposed score for predicting severe infection complications in children with chemotherapy-induced febrile neutropenia en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Canc AC Camargo
dc.description.affiliation Hosp Canc AC Camargo, Ctr Tratamento & Pesquisa, Dept Pediat, BR-01509000 São Paulo, Brazil
dc.description.affiliation Hosp Canc AC Camargo, Canc Registry, BR-01509000 São Paulo, Brazil
dc.identifier.doi 10.1097/01.mph.0000212996.94929.0b
dc.description.source Web of Science
dc.identifier.wos WOS:000242395600006


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