Diagnosis of epithelial ingrowth after penetrating keratoplasty with confocal microscopy

Diagnosis of epithelial ingrowth after penetrating keratoplasty with confocal microscopy

Author Forseto, Adriana dos Santos Google Scholar
Santos, Myrna Serapiao dos Google Scholar
Sampaio, Angelica Google Scholar
Mascaro, Vera Google Scholar
Nose, Walton Google Scholar
Institution Eye Clin Day Hosp
Universidade Federal de São Paulo (UNIFESP)
Hosp Servidor Publ Estadual
Abstract Purpose: To report confocal microscopy use in the clinical diagnosis of epithelial ingrowth after penetrating keratoplasty (PKP).Methods: A 36-year-old female patient with keratoconus developed a well-delimited posterior hazy membrane covering the inferior two thirds of the cornea 3 months after an uneventful PKP. A posterior corneal line was present resembling an endothelial graft rejection line, but with no keratic precipitates or corneal edema. Ocular hypertension was not observed, Confocal microscopy was performed to elucidate the diagnosis.Results: Confocal microscopy showed epithelium and stroma with normal findings. Two distinct cellular types were presented at the endothelium layer. Enlarged endothelial cells were observed in the superior part of the cornea up to the leading edge of the hazy membrane. in the middle and inferior part of the graft, the cells were larger, with polygonal shape and easily recognizable hyperreflective nuclei, suggestive of epithelial cells. With these confocal microscopy findings, the patient was promptly submitted to another PKP. Histologic analysis confirmed the diagnosis of epithelial ingrowth.Conclusion: Confocal microscopy imaging technique seems to be a useful tool in the early diagnosis of epithelial ingrowth after PKP.
Keywords confocal microscopy
epithelial ingrowth
Language English
Date 2006-10-01
Published in Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 25, n. 9, p. 1124-1127, 2006.
ISSN 0277-3740 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1124-1127
Origin http://dx.doi.org/10.1097/01.ico.0000228787.92205.3b
Access rights Closed access
Type Article
Web of Science ID WOS:000242701400029
URI http://repositorio.unifesp.br/handle/11600/29196

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