Effects of chronic stavudine exposure on liver, pancreas and kidneys of pregnant rats and their fetuses: Morphological and biochemical aspects

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dc.contributor.author Barreto, Regina Lucia Braga
dc.contributor.author Soares, Jose Maria
dc.contributor.author Simoes, Ricardo Santos
dc.contributor.author Maciel, Gustavo Arantes Rosa
dc.contributor.author Jesus Simoes, Manuel de
dc.contributor.author Kulay, Luiz
dc.date.accessioned 2016-01-24T12:41:26Z
dc.date.available 2016-01-24T12:41:26Z
dc.date.issued 2006-09-01
dc.identifier http://dx.doi.org/10.1016/j.ejogrb.2005.12.027
dc.identifier.citation European Journal of Obstetrics Gynecology and Reproductive Biology. Clare: Elsevier B.V., v. 128, n. 1-2, p. 50-53, 2006.
dc.identifier.issn 0301-2115
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29130
dc.description.abstract Objective: To study the morphological and biochemical effects on liver, pancreas and kidney of pregnant rats and their fetuses subjected to stavudine treatment.Methods: Forty animals were distributed in four groups E1, E2, E3, and C (control) and received by gavage once a day 1, 3 or 9 mg/kg of stavudine in 2 mL distilled water, from days 1 to 20 of pregnancy. After this period, the animals were sacrificed; blood samples were collected for further determinations of AST, ALT, creatinine, urea, glucose and amylase. Samples of liver, kidneys and pancreas of every rat and of the corresponding fetuses were taken and examined under light microscopy.Results: the maternal livers of groups E1, E2 and E3 displayed progressive morphological alterations without corresponding changes in serum AST and ALT activity. Maternal kidney histology and function were similar in all groups. Maternal pancreas of groups E2 and E3 evidenced moderate and progressive signs of tissue damage without functional repercussion. All fetal livers, kidneys and pancreas presented normal morphology.Conclusions: High doses of stavudine produced signs of mild to moderate maternal hepatic and pancreatic toxicity at the morphological level. This was not followed by changes in biochemical parameters, most conceivably due to the functional reserve of these organs. (C) 2006 Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 50-53
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof European Journal of Obstetrics Gynecology and Reproductive Biology
dc.rights Acesso restrito
dc.subject stavudine en
dc.subject liver en
dc.subject pancreas en
dc.subject kidney en
dc.subject fetus en
dc.subject pregnancy en
dc.subject rat en
dc.title Effects of chronic stavudine exposure on liver, pancreas and kidneys of pregnant rats and their fetuses: Morphological and biochemical aspects en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Obstet, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Obstet, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Morphol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.ejogrb.2005.12.027
dc.description.source Web of Science
dc.identifier.wos WOS:000240909100009



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