Effect of end-stage renal disease and diabetes on zinc and copper status

Effect of end-stage renal disease and diabetes on zinc and copper status

Author Batista, Maria Nazare Google Scholar
Cuppari, Lilian Google Scholar
Campos Pedrosa, Lucia de Fatima Google Scholar
Almeida, Maria Das Gracas Google Scholar
De Almeida, Jose Bruno Google Scholar
Queiroz de Medeiros, Anna Cecilia Google Scholar
Canziani, Maria Eugienia F. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande Norte
Abstract The aim of this study was to compare the nutritional status of zinc and copper in patients with and without diabetes submitted to chronic hemodialysis. Thirty-three patients with type 2 diabetes (DM group), 30 nondiabetic patients (NDM group), and 20 healthy individuals (control group) were studied. Plasma, erythrocyte, and urinary zinc and plasma copper were obtained from atomic absorption spectrophotometry and ceruloplasmin by immunonephelometry. the anthropometric parameters were similar among the groups. Plasma zinc was lower and erythrocyte zinc was higher in the DM and NDM groups in relation to the control group. No difference in urinary zinc was observed comparing the groups. Plasma copper was higher in the DM group when compared to the NDM and control groups. Ceruloplasmin was similar in the three groups. Serum urea was a positive independent determinant of plasma zinc concentrations. the determinants of erythrocyte zinc were MAMC midarm muscle circumference and Kt/V dialysis adequacy. the determinants of plasma copper concentration were serum creatinine and serum glucose. the results of this study demonstrate an alteration in the distribution of zinc in patients with chronic kidney disease (CKD) independently of the presence of DM. Also, the status of copper seems not to be influenced by CKD, but only by the metabolic derangements associated with diabetes.
Keywords zinc
copper
chronic kidney disease
hemodialysis
diabetes
Language English
Date 2006-07-01
Published in Biological Trace Element Research. Totowa: Humana Press Inc, v. 112, n. 1, p. 1-12, 2006.
ISSN 0163-4984 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 1-12
Origin http://dx.doi.org/10.1385/BTER:112:1:1
Access rights Closed access
Type Article
Web of Science ID WOS:000240218100001
URI http://repositorio.unifesp.br/handle/11600/29045

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