Tacrolimus and quality of life after kidney transplantation - a multicenter study

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dc.contributor.author Bohlke, M.
dc.contributor.author Rocha, M.
dc.contributor.author Gomes, R. H.
dc.contributor.author Marini, S. S.
dc.contributor.author Terhorst, L.
dc.contributor.author Barcellos, F. C.
dc.contributor.author Hallal, P. C.
dc.contributor.author Casarini, D.
dc.contributor.author Irigoyen, M. C.
dc.date.accessioned 2016-01-24T12:41:20Z
dc.date.available 2016-01-24T12:41:20Z
dc.date.issued 2006-07-01
dc.identifier http://dx.doi.org/10.1111/j.1399-0012.2006.00513.x
dc.identifier.citation Clinical Transplantation. Oxford: Blackwell Publishing, v. 20, n. 4, p. 504-508, 2006.
dc.identifier.issn 0902-0063
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29041
dc.description.abstract Kidney transplantation is currently the treatment of choice for end-stage renal disease. Although new immunosuppressive drugs have been introduced into clinical practice, the effect of such medication on quality of life (QoL) in transplant recipients is still unclear. the present study analyzes the impact of tacrolimus-based immunosuppression on QoL in a representative sample of adult kidney transplant recipients from Rio Grande do Sul, a Brazilian southern state. This was a cross-sectional multicenter study which used the SF-36 Health Survey for measuring QoL. the effect of tacrolimus on QoL was adjusted for possible confounders using multiple linear regression. A total of 272 patients (from 11 different centers) were evaluated, 48 of them were treated with tacrolimus. Transplant patients in use of tacrolimus presented significant higher scores in the physical component summary of SF-36 than non-users (49.1 +/- 8.3 vs. 46.1 +/- 8.7; p = 0.03), and such difference was noted in the physical functioning and general health subscales (81.5 +/- 17.1 and 74.7 +/- 21.8; 74.6 +/- 22.3 and 67.1 +/- 22.3 for users and non-users of tacrolimus, respectively, p < 0.05). the effect of tacrolimus remained significant after adjustment for age, gender, skin color and time since transplantation (coeff.: 2.83; 95% CI: 0.05-5.6, p = 0.045). the association between tacrolimus-based immunosuppression and better perception of physical functioning and general health for renal transplant patients represents a significant finding as it may influence therapeutical decisions and contribute to maximize kidney transplantation benefits. en
dc.format.extent 504-508
dc.language.iso eng
dc.publisher Blackwell Publishing
dc.relation.ispartof Clinical Transplantation
dc.rights Acesso restrito
dc.subject immunosuppression en
dc.subject kidney transplantation en
dc.subject quality of life en
dc.subject tacrolimus en
dc.title Tacrolimus and quality of life after kidney transplantation - a multicenter study en
dc.type Artigo
dc.contributor.institution Catholic Univ Pelotas
dc.contributor.institution Fed Univ Pelotas
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Catholic Univ Pelotas, Sch Med, Pelotas, Brazil
dc.description.affiliation Fed Univ Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Postgrad Program Nephrol, São Paulo, Brazil
dc.description.affiliation FMUSP, INCOR, Hypertens Unit, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Postgrad Program Nephrol, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1399-0012.2006.00513.x
dc.description.source Web of Science
dc.identifier.wos WOS:000238743900017


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