Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice

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dc.contributor.author Claro, Flavia T.
dc.contributor.author Patti, Camilla L.
dc.contributor.author Abilio, Vanessa C.
dc.contributor.author Frussa-Filho, Roberto
dc.contributor.author Silva, Regina H.
dc.date.accessioned 2016-01-24T12:41:19Z
dc.date.available 2016-01-24T12:41:19Z
dc.date.issued 2006-07-01
dc.identifier http://dx.doi.org/10.1016/j.pnpbp.2006.01.013
dc.identifier.citation Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 30, n. 5, p. 881-886, 2006.
dc.identifier.issn 0278-5846
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29015
dc.description.abstract This study verifies the effects of bovine brain phosphatidylserine (PS) on passive avoidance (PA) and contextual fear conditioning (CFC) tests in scopolamine-treated mice. Mice received daily i.p. 50 mg/kg PS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. On day 6, mice received saline (TRIS-SAL and PS-SAL) or 1 mg/kg SCO (TRIS-SCO and PS-SCO) i.p. After 20 min, the animals were submitted to PA (experiment 1) or CFC (experiment 2) training sessions, and tests were performed 24 h later. Latency in entering the dark chamber of the PA apparatus presented by TRIS-SCO (but not PS-SCO) group in the test was significantly higher than those presented by controls. Except for TRIS-SCO, all the groups presented higher latencies in the test compared to the training session. in experiment 2, the TRIS-SCO (but not PS-SCO) group presented significantly lower freezing duration than that presented by the TRIS-SAL group in the test. Animals treated with PS alone presented higher freezing duration than that presented by the TRIS-SAL group. the results demonstrate that PS attenuates SCO-induced amnesia in both PA and CFC tests. in addition, PS per se improves retention in the CFC test. (c) 2006 Elsevier Inc. All rights reserved. en
dc.format.extent 881-886
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Progress in Neuro-psychopharmacology & Biological Psychiatry
dc.rights Acesso restrito
dc.subject behavior en
dc.subject learning en
dc.subject memory en
dc.subject mice en
dc.subject phosphatidylserine en
dc.subject scopolamine en
dc.title Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice en
dc.type Resenha
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/j.pnpbp.2006.01.013
dc.description.source Web of Science
dc.identifier.wos WOS:000238458200011



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