Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice

Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice

Author Claro, Flavia T. Google Scholar
Patti, Camilla L. Google Scholar
Abilio, Vanessa C. Google Scholar
Frussa-Filho, Roberto Google Scholar
Silva, Regina H. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study verifies the effects of bovine brain phosphatidylserine (PS) on passive avoidance (PA) and contextual fear conditioning (CFC) tests in scopolamine-treated mice. Mice received daily i.p. 50 mg/kg PS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. On day 6, mice received saline (TRIS-SAL and PS-SAL) or 1 mg/kg SCO (TRIS-SCO and PS-SCO) i.p. After 20 min, the animals were submitted to PA (experiment 1) or CFC (experiment 2) training sessions, and tests were performed 24 h later. Latency in entering the dark chamber of the PA apparatus presented by TRIS-SCO (but not PS-SCO) group in the test was significantly higher than those presented by controls. Except for TRIS-SCO, all the groups presented higher latencies in the test compared to the training session. in experiment 2, the TRIS-SCO (but not PS-SCO) group presented significantly lower freezing duration than that presented by the TRIS-SAL group in the test. Animals treated with PS alone presented higher freezing duration than that presented by the TRIS-SAL group. the results demonstrate that PS attenuates SCO-induced amnesia in both PA and CFC tests. in addition, PS per se improves retention in the CFC test. (c) 2006 Elsevier Inc. All rights reserved.
Keywords behavior
learning
memory
mice
phosphatidylserine
scopolamine
Language English
Date 2006-07-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 30, n. 5, p. 881-886, 2006.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 881-886
Origin http://dx.doi.org/10.1016/j.pnpbp.2006.01.013
Access rights Closed access
Type Review
Web of Science ID WOS:000238458200011
URI http://repositorio.unifesp.br/handle/11600/29015

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