Human colostrum contains IgA antibodies reactive to colonization factors I and II of enterotoxigenic Escherichia coli

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dc.contributor.author Correa, Simone
dc.contributor.author Palmeira, Patricia
dc.contributor.author Carneiro-Sampaio, Magda Maria Sales
dc.contributor.author Nishimura, Lucília Sanae [UNIFESP]
dc.contributor.author Guth, Beatriz Ernestina Cabilio [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:16Z
dc.date.available 2016-01-24T12:41:16Z
dc.date.issued 2006-07-01
dc.identifier http://dx.doi.org/10.1111/j.1574-695X.2006.00082.x
dc.identifier.citation Fems Immunology and Medical Microbiology. Oxford: Blackwell Publishing, v. 47, n. 2, p. 199-206, 2006.
dc.identifier.issn 0928-8244
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28992
dc.description.abstract Diarrhea is an important cause of morbidity and mortality amongst infants of low socio-economic levels in developing countries and in travelers who visit such areas. Enterotoxigenic E. coli strains express two sets of virulence-associated factors: enterotoxins (heat-stable toxins or heat-labile toxins) and colonization factors. Studies have shown that breast-feeding protects infants against infectious diseases, such as diarrhea, as it presents a great variety of immunological components. the aim of this study was to analyze the reactivity of immunoglobulin A from human colostrum to colonization factor antigens I and II. the colostrum ability in preventing enterotoxigenic E. coli adhesion to Caco-2 cells was also evaluated. Colostrum samples were collected from 32 healthy women, and a human colostrum. pool was prepared. Enterotoxigenic E. coli strains expressing colonization factor antigens I and 11 were utilized. the colostrum pool and individual samples showed variable antienterotoxigenic E. coli immunoglobulin A titers, that were reactive with colonization factor antigen I and CS1/CS3 (colonization factor antigen 11). the human colostrum pool and individual samples inhibited enterotoxigenic E coli colonization factor antigen I and II adhesion to Caco-2 cells, at variable levels, and this ability was a result of immunoglobulin A antibodies reactive to these colonization factors. the immunoglobulin A-depleted pool lost this inhibitory ability. As bacterial adhesion is the initial mechanism of enterotoxigenic E. coli infection, breast-feeding could protect the offspring against diarrhea caused by this agent. en
dc.format.extent 199-206
dc.language.iso eng
dc.publisher Blackwell Publishing
dc.relation.ispartof Fems Immunology and Medical Microbiology
dc.rights Acesso aberto
dc.subject enterotoxigenic en
dc.subject Escherichia coli en
dc.subject secretory IgA en
dc.subject colonization factor antigen I en
dc.subject colonization factor antigen II en
dc.subject human colostrum en
dc.title Human colostrum contains IgA antibodies reactive to colonization factors I and II of enterotoxigenic Escherichia coli en
dc.type Artigo
dc.contributor.institution Inst Ciencias Biomed
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Inst Ciencias Biomed, Lab Imunol Mucosas, BR-05503900 São Paulo, SP, Brazil
dc.description.affiliation Univ São Paulo, Dept Immunol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1574-695X.2006.00082.x
dc.description.source Web of Science
dc.identifier.wos WOS:000238761500005



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