Correlation of c-erbB-2 oncogene and p53 tumor suppressor gene with malignant transformation of hydatidiform mole

Correlation of c-erbB-2 oncogene and p53 tumor suppressor gene with malignant transformation of hydatidiform mole

Autor Sun, Sue Yasaki Autor UNIFESP Google Scholar
Daher, S. Google Scholar
Ishigai, MMD Google Scholar
Alves, MTS Google Scholar
Mantovani, T. M. Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Considering the roles of c-erB-2 and p53 oncoproteins in tumor progression, we aimed to evaluate their expression in hydatidiform moles, and the possible predictive value of this immunoexpression in postmolar follow-up.Group I comprised 35 patients with progression to gestational trophoblastic tumor, and group II included 32 patients with progression to spontaneous remission. Immunohistochemical tests were performed by streptavidin-peroxidase method. c-erbB-2 immunoexpression was evaluated according to quantitative and semiquantitative criteria; p53 according to percentage of cells with stained nuclei. Data were analyzed by Student t-test, Mann-Whitney test, ROC curve and logistic regression analysis.c-erbB-2 and p-53 expressions were significantly increased in group I. Quantitative and semiquantitative analysis of c-erb-2 showed that its expression may be associated with mole hydatidiform progression to gestational trophoblastic tumor. Taking into account cells with complete membranous delineation we proposed a cut-off value of 10.8%. Similarly, considering the percentage of cells presenting nuclei marked by p53 we suggested a cut-off value of 40.1% for the prediction of malignant transformation of mole hydatidiform.c-erbB-2 and p53 immunoexpression in hydatidiform mole are usually increased with malignant transformation. in addition to beta-fraction of human chorionic gonadotropin, they could possibly help the establishment of a therapeutic protocol.
Palavra-chave c-erbB-2
complete hydatidiform mole
gestational trophoblast tumor
oncogene
p53
Idioma Inglês
Data de publicação 2006-06-01
Publicado em Journal of Obstetrics and Gynaecology Research. Oxford: Blackwell Publishing, v. 32, n. 3, p. 265-272, 2006.
ISSN 1341-8076 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 265-272
Fonte http://dx.doi.org/10.1111/j.1447-0756.2006.00397.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000237694700001
Endereço permanente http://repositorio.unifesp.br/handle/11600/28970

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