Role of the paratrigeminal nucleus in nocifensive responses of rats to chemical, thermal and mechanical stimuli applied to the hind paw

Role of the paratrigeminal nucleus in nocifensive responses of rats to chemical, thermal and mechanical stimuli applied to the hind paw

Autor Koepp, J. Google Scholar
Lindsey, C. J. Google Scholar
Motta, E. M. Google Scholar
Rae, G. A. Google Scholar
Instituição Universidade Federal de Santa Catarina (UFSC)
Universidade Federal de São Paulo (UNIFESP)
Resumo Anatomical and immunohystochemical data suggest the paratrigeminal nucleus (Pa5) may play a role in nociceptive processing. the current study examines the influence of unilateral Pa5 lesion on nocifensive responses of conscious rats to noxious thermal (Hargreaves test), mechanical (electronic von Frey and Randall-Selitto tests), and chemical (formalin 2.5%; 50 mu l) stimuli applied to the hind paw. Lesion of the Pa5 induced by ibotenic acid did not affect the latency for radiant heat-induced withdrawal of either paw. in contrast, the mean mechanical threshold for withdrawal of the contralateral (but not ipsilateral) paw in Pa5-lesioned rats was reduced by approximately 45% and 20%. in electronic von Frey and Randall-Selitto tests, respectively, when compared to sham-operated animals. Conversely. animals with Pa5 lesions injected with formalin in the contralateral paw spent less time engaged in focused (licking, biting or scratching the injected paw) and total nocifensive behavior (i.e., focused nocifensive behavior plus protection of the injected paw during movements) in both the first and second phases of the test [similar to 50% inhibition of each parameter during first phase (0-5 min) and at 20, 25, and 30 min of second phase, relative to the sham-operated group], but the number of paw-jerks was Unaffected. Pa5 lesion also delayed the onset of second phase focused pain induced by formalin in the ipsilateral paw. the results Suggest that the Pa5 integrates the supraspinal pain control system and plays a differential modulatory role in the central processing of mechanical and chemical nociceptive information. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
Palavra-chave paratrigeminal nucleus
ibotenic acid lesion
noxious stimulation
pain
nociception
supraspinal pain control system
Idioma Inglês
Data de publicação 2006-06-01
Publicado em Pain. Amsterdam: Elsevier B.V., v. 122, n. 3, p. 235-244, 2006.
ISSN 0304-3959 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 235-244
Fonte http://dx.doi.org/10.1016/j.pain.2006.01.038
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000238456000004
Endereço permanente http://repositorio.unifesp.br/handle/11600/28955

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