Comparative study of ocular herpes simplex virus in patients with and without self-reported atopy

Comparative study of ocular herpes simplex virus in patients with and without self-reported atopy

Autor Rezende, R. A. Google Scholar
Hammersmith, K. Google Scholar
Bisol, T. Google Scholar
Lima, ALH Google Scholar
Webster, G. F. Google Scholar
Freitas, J. F. Google Scholar
Rapuano, C. J. Google Scholar
Laibson, P. R. Google Scholar
Cohen, E. J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Thomas Jefferson Univ
Cent Hosp Brazilian Air Force
Resumo PURPOSE: To compare the characteristics of ocular herpes simplex virus (HSV) in patients with and without atopy.DESIGN: Retrospective cohort comparative study.METHODS: Patients who presented at the Cornea Service, Wills Eye Hospital, between March 2003 and March 2004 who had been previously diagnosed in the same institution as having ocular HSV diagnosis or were just diagnosed as having the disease were asked to complete a study questionnaire that enabled categorization into atopic and nonatopic. in April 2005, 223 patients who agreed to be in the study had their charts reviewed, and 125 patients were excluded according to exclusion criteria: immunosuppression, follow,up, less than one year, previous history of penetrating keratoplasty (PK) out of the Cornea Service, and no active HSV episode during follow-up. MAIN OUTCOME MEASURES: Incidence of all types of HSV recurrences. SECONDARY OUTCOME MEASums: Bilaterality, visual loss, need for PK, and second, ary bacterial infection in both groups. HSV episodes were classified into infectious, inflammatory, and mixed for analysis.RESULTS: Ninety eight patients (110 eyes) were included in the study. Atopic/nonatopic (P value): the mean follow-up was 11.6 (+/- 10.6)/8.8 years (+/- 8.4) (P =.14); the mean incidence of HSV episodes per year of follow-up was: total episodes 0.32 (+/- 0.36)/0.28 (+/- 0.33) (P =.14), infectious 0.16 (+/- 0.22)/0.10 (+/- 0.14) (P <.01), inflammatory 0.11 (+/- 0.19)/0.11 (+/- 0.19) (P <.01), and mixed 0.09 (+/- 0.20)/0.07 (+/- 0.16) (P =.06); bilateral HSV was present in 9/3 patients (P =.22); the mean loss of vision was four lines of Snellen in both groups; PK was performed in 14 of 16 eyes (P =.45); secondary bacterial infection was present in two of four eyes (P =.26).CONCLUSIONS: Atopic patients had considerably more infectious and fewer inflammatory episodes when compared with nonatopics.
Idioma Inglês
Data 2006-06-01
Publicado em American Journal of Ophthalmology. New York: Elsevier B.V., v. 141, n. 6, p. 1120-1125, 2006.
ISSN 0002-9394 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 1120-1125
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000238492600018

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