Biomolecular study of the correlation between papillomatosis of the vulvar vestibule in adolescents and human papillomavirus

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dc.contributor.author Beznos, Geni
dc.contributor.author Coates, Veronica
dc.contributor.author Focchi, José [UNIFESP]
dc.contributor.author Omar, Hatim A.
dc.date.accessioned 2016-01-24T12:41:12Z
dc.date.available 2016-01-24T12:41:12Z
dc.date.issued 2006-06-01
dc.identifier http://dx.doi.org/10.1100/tsw.2006.130
dc.identifier.citation Thescientificworldjournal. Newbury: Thescientificworld Ltd, v. 6, p. 628-636, 2006.
dc.identifier.issn 1537-744X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28922
dc.description.abstract The main goal of this study was to investigate, through a biomolecular study, the correlation between papillomatosis of the vulvar vestibule and human papillomavirus (HPV) infection, as well as to establish the necessity of treatment. A total of 44 female adolescents between 12 and 18 years of age were selected through a prospective study with a confirmed diagnosis of papillomatosis of the vulvar vestibule. Vulvar biopsies were obtained for the histological and biomolecular detection of HPV DNA through polymerase chain reaction (PCR). Twenty (45%) adolescents were virgins (group A), the other 24 (55%) were sexually active. the virgin adolescents (group A) and 12 sexually active adolescents (group B) did not show cytological and/or colposcopic alteration, suggesting infection by HPV either on the cervix or vagina. These were compared with 12 other sexually active adolescents who showed cervicovaginal infection caused by HPV (group C). Fisher exact test was applied for statistical analysis of the results, considering alpha equal or less than 0.05. There was no statistically significant difference in relation to HPV DNA through PCR among virgin and sexually active adolescents in group B, however, both differed from those in group C (A + B x C: p = 0.048*). the histological study did not reveal evident signs of infection caused by HPV on vestibular papillae, besides perinuclear halos. HPV DNA was detected on vestibular papillae in 27%. Our results confirmed a scarce correlation between vestibular papillae and HPV. Thus, we consider papillomatosis of the vulvar vestibule, in most cases, to be equivalent to physiological papillomatosis and, therefore, should not be treated. en
dc.format.extent 628-636
dc.language.iso eng
dc.publisher Thescientificworld Ltd
dc.relation.ispartof Thescientificworldjournal
dc.rights Acesso aberto
dc.subject HPV en
dc.subject papillomatosis en
dc.subject adolescents en
dc.subject Brazil en
dc.subject United States en
dc.title Biomolecular study of the correlation between papillomatosis of the vulvar vestibule in adolescents and human papillomavirus en
dc.type Artigo
dc.contributor.institution Univ Kentucky
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Kentucky, Dept Pediat, Lexington, KY USA
dc.description.affiliation Fac Med Sci, Adolescent Clin Unit, Dept Pediat, Irmandade Santa Casa Misericordia São Paulo, São Paulo, Brazil
dc.identifier.file WOS000242388500004.pdf
dc.identifier.doi 10.1100/tsw.2006.130
dc.description.source Web of Science
dc.identifier.wos WOS:000242388500004



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