Biomolecular study of the correlation between papillomatosis of the vulvar vestibule in adolescents and human papillomavirus

Biomolecular study of the correlation between papillomatosis of the vulvar vestibule in adolescents and human papillomavirus

Author Beznos, Geni Google Scholar
Coates, Veronica Google Scholar
Focchi, José Autor UNIFESP Google Scholar
Omar, Hatim A. Google Scholar
Institution Univ Kentucky
Universidade Federal de São Paulo (UNIFESP)
Abstract The main goal of this study was to investigate, through a biomolecular study, the correlation between papillomatosis of the vulvar vestibule and human papillomavirus (HPV) infection, as well as to establish the necessity of treatment. A total of 44 female adolescents between 12 and 18 years of age were selected through a prospective study with a confirmed diagnosis of papillomatosis of the vulvar vestibule. Vulvar biopsies were obtained for the histological and biomolecular detection of HPV DNA through polymerase chain reaction (PCR). Twenty (45%) adolescents were virgins (group A), the other 24 (55%) were sexually active. the virgin adolescents (group A) and 12 sexually active adolescents (group B) did not show cytological and/or colposcopic alteration, suggesting infection by HPV either on the cervix or vagina. These were compared with 12 other sexually active adolescents who showed cervicovaginal infection caused by HPV (group C). Fisher exact test was applied for statistical analysis of the results, considering alpha equal or less than 0.05. There was no statistically significant difference in relation to HPV DNA through PCR among virgin and sexually active adolescents in group B, however, both differed from those in group C (A + B x C: p = 0.048*). the histological study did not reveal evident signs of infection caused by HPV on vestibular papillae, besides perinuclear halos. HPV DNA was detected on vestibular papillae in 27%. Our results confirmed a scarce correlation between vestibular papillae and HPV. Thus, we consider papillomatosis of the vulvar vestibule, in most cases, to be equivalent to physiological papillomatosis and, therefore, should not be treated.
Keywords HPV
papillomatosis
adolescents
Brazil
United States
Language English
Date 2006-06-01
Published in Thescientificworldjournal. Newbury: Thescientificworld Ltd, v. 6, p. 628-636, 2006.
ISSN 1537-744X (Sherpa/Romeo, impact factor)
Publisher Thescientificworld Ltd
Extent 628-636
Origin http://dx.doi.org/10.1100/tsw.2006.130
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000242388500004
URI http://repositorio.unifesp.br/handle/11600/28922

Show full item record




File

Name: WOS000242388500004.pdf
Size: 1.249Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account