Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-Infected individuals from Botswana and Cameroon

Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-Infected individuals from Botswana and Cameroon

Autor Gupta, S. B. Google Scholar
Mast, C. T. Google Scholar
Wolfe, N. D. Google Scholar
Novitsky, V Google Scholar
Dubey, S. A. Google Scholar
Kallas, Esper Georges Autor UNIFESP Google Scholar
Schechter, M. Google Scholar
Mbewe, B. Google Scholar
Vardas, E. Google Scholar
Pitisuttithum, P. Google Scholar
Burke, D. Google Scholar
Freed, D. Google Scholar
Mogg, R. Google Scholar
Coplan, P. M. Google Scholar
Condra, J. H. Google Scholar
Long, R. S. Google Scholar
Anderson, K. Google Scholar
Casimiro, D. R. Google Scholar
Shiver, J. W. Google Scholar
Straus, W. L. Google Scholar
Instituição Merck & Co Inc
Johns Hopkins Bloomberg Sch Publ Hlth
Harvard Univ
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Malawi Coll Med
Minist Populat & Hlth
Univ Witwatersrand
Mahidol Univ
Int Partnership Microbicides
Resumo An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.
Palavra-chave HIV
cell-mediated immunity
viral clade
Idioma Inglês
Data de publicação 2006-06-01
Publicado em Jaids-Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 2, p. 135-139, 2006.
ISSN 1525-4135 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 135-139
Fonte http://dx.doi.org/10.1097/01.qai.0000223017.01568.e7
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000237910700001
Endereço permanente http://repositorio.unifesp.br/handle/11600/28921

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