Towards a vaccine against rheumatic fever

Exibir registro simples Guilherme, L. Fae, K. C. Higa, F. Chaves, L. Oshiro, S. E. De Barros, S. Freschi Puschel, C. Juliano, Maria Aparecida [UNIFESP] Tanaka, A. C. Spina, G. Kalil, J. 2016-01-24T12:41:11Z 2016-01-24T12:41:11Z 2006-06-01
dc.identifier.citation Clinical & Developmental Immunology. Philadelphia: Taylor & Francis Inc, v. 13, n. 2-4, p. 125-132, 2006.
dc.identifier.issn 1740-2522
dc.description.abstract Rheumatic fever (RF) is an autoimmune disease which affects more than 20 million children in developing countries. It is triggered by Streptococcus pyogenes throat infection in untreated susceptible individuals. Carditis, the most serious manifestation of the disease, leads to severe and permanent valvular lesions, causing chronic rheumatic heart disease (RHD). We have been studying the mechanisms leading to pathological autoimmunity in RF/RHD for the last 15 years. Our studies allowed us a better understanding of the cellular and molecular pathogenesis of RHD, paving the way for the development of a safe vaccine for a post-infection autoimmune disease. We have focused on the search for protective Tand B cell epitopes by testing 620 human blood samples against overlapping peptides spanning 99 residues of the C-terminal portion of the M protein, differing by one amino acid residue. We identified Tand B cell epitopes with 22 and 25 amino acid residues, respectively. Although these epitopes were from different regions of the C-terminal portion of the M protein, they showed an identical core of 16 amino acid residues. Antibodies against the B cell epitope inhibited bacterial invasion/adhesion in vitro. Our results strongly indicated that the selected T and B cell epitopes could potentially be protective against S. pyogenes. en
dc.format.extent 125-132
dc.language.iso eng
dc.publisher Taylor & Francis Inc
dc.relation.ispartof Clinical & Developmental Immunology
dc.rights Acesso aberto
dc.subject rheumatic fever en
dc.subject Streptococcus pyogenes en
dc.subject T and B cell protective epitopes en
dc.subject vaccine en
dc.title Towards a vaccine against rheumatic fever en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Millennium Inst
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Sch Med, Heart Inst InCor, São Paulo, Brazil
dc.description.affiliation Millennium Inst, Inst Invest Immunol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Dept Clin Med, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1080/17402520600877026
dc.description.source Web of Science
dc.identifier.wos WOS:000243126000005


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