Towards a vaccine against rheumatic fever

Towards a vaccine against rheumatic fever

Autor Guilherme, L. Google Scholar
Fae, K. C. Google Scholar
Higa, F. Google Scholar
Chaves, L. Google Scholar
Oshiro, S. E. Google Scholar
De Barros, S. Freschi Google Scholar
Puschel, C. Google Scholar
Juliano, Maria Aparecida Autor UNIFESP Google Scholar
Tanaka, A. C. Google Scholar
Spina, G. Google Scholar
Kalil, J. Google Scholar
Instituição Universidade de São Paulo (USP)
Millennium Inst
Universidade Federal de São Paulo (UNIFESP)
Resumo Rheumatic fever (RF) is an autoimmune disease which affects more than 20 million children in developing countries. It is triggered by Streptococcus pyogenes throat infection in untreated susceptible individuals. Carditis, the most serious manifestation of the disease, leads to severe and permanent valvular lesions, causing chronic rheumatic heart disease (RHD). We have been studying the mechanisms leading to pathological autoimmunity in RF/RHD for the last 15 years. Our studies allowed us a better understanding of the cellular and molecular pathogenesis of RHD, paving the way for the development of a safe vaccine for a post-infection autoimmune disease. We have focused on the search for protective Tand B cell epitopes by testing 620 human blood samples against overlapping peptides spanning 99 residues of the C-terminal portion of the M protein, differing by one amino acid residue. We identified Tand B cell epitopes with 22 and 25 amino acid residues, respectively. Although these epitopes were from different regions of the C-terminal portion of the M protein, they showed an identical core of 16 amino acid residues. Antibodies against the B cell epitope inhibited bacterial invasion/adhesion in vitro. Our results strongly indicated that the selected T and B cell epitopes could potentially be protective against S. pyogenes.
Palavra-chave rheumatic fever
Streptococcus pyogenes
T and B cell protective epitopes
vaccine
Idioma Inglês
Data de publicação 2006-06-01
Publicado em Clinical & Developmental Immunology. Philadelphia: Taylor & Francis Inc, v. 13, n. 2-4, p. 125-132, 2006.
ISSN 1740-2522 (Sherpa/Romeo, fator de impacto)
Publicador Taylor & Francis Inc
Extensão 125-132
Fonte http://dx.doi.org/10.1080/17402520600877026
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000243126000005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28917

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