Clinical co-morbidities in obstructive sleep apnea syndrome treated with mandibular repositioning appliance

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dc.contributor.author Machado, Marco Antonio Cardoso [UNIFESP]
dc.contributor.author Carvalho, Luciane Bizari Coin de [UNIFESP]
dc.contributor.author Juliano, Maria Ligia [UNIFESP]
dc.contributor.author Taga, Marcel Frederico de Lima [UNIFESP]
dc.contributor.author Prado, Lucila Bizari Fernandes do [UNIFESP]
dc.contributor.author Prado, Gilmar Fernandes do [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:11Z
dc.date.available 2016-01-24T12:41:11Z
dc.date.issued 2006-06-01
dc.identifier http://dx.doi.org/10.1016/j.rmed.2005.10.002
dc.identifier.citation Respiratory Medicine. London: W B Saunders Co Ltd, v. 100, n. 6, p. 988-995, 2006.
dc.identifier.issn 0954-6111
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28915
dc.description.abstract Introduction: Intraoral mandibular repositioner appliances (IOMRAs) are designed to enlarge pharyngeal airway space advancing the mandible and increasing genioglossus tone during sleep. Obstructive sleep apnea syndrome (OSAS) treatment with IOMRAs is beneficial, but there is a lack of studies in the literature defining the target population more inclined to respond to this treatment.Methods: We contacted by telephone 188 previously treated patients with IOMRA, detecting 20 not improved patients (Study Group). Twenty improved patients of the remaining 168 were randomly paired according to gender, age, apnea, and hypopnea index as Control Group. Both groups answered questionnaires for diagnosis of sleep disorders, depression, anxiety, and the Epworth sleepiness scale. We did a descriptive and inferential statistical analysis. the inferential analysis was divided into two steps: univariate analysis using Fischer exact test and a multiple inferential analysis using a stepwise regression model.Results: Although the final model included only insomnia, we concluded that the presence of gastric, neurological and rheumatic diseases also tended to be associated with the self-perception of non-improvement. the association between the accumulation of gastric, neurological, and rheumatic diseases and insomnia and improvement demonstrated that an increase in one of these diseases correspond to a two-fold increase in the chance of non-improvement.Conclusions: Insomnia was the most important factor compromising the, success of OSAS treatment with IOMRAs, and the isolated presence of gastric, neurological and rheumatic diseases, but especially their combination, reduces the perception rate of welt-succeeded treatment with IOMRAs. (c) 2005 Elsevier B.V. All rights reserved. en
dc.format.extent 988-995
dc.language.iso eng
dc.publisher W B Saunders Co Ltd
dc.relation.ispartof Respiratory Medicine
dc.rights Acesso aberto
dc.subject insomnia en
dc.subject sleep apnea en
dc.subject intraoral appliances en
dc.subject adult en
dc.title Clinical co-morbidities in obstructive sleep apnea syndrome treated with mandibular repositioning appliance en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, BR-04039002 São Paulo, Brazil
dc.identifier.file WOS000238016500005.pdf
dc.identifier.doi 10.1016/j.rmed.2005.10.002
dc.description.source Web of Science
dc.identifier.wos WOS:000238016500005



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