Effect of oral diacerein (DAR) in an experimental hip chondrolysis model

Effect of oral diacerein (DAR) in an experimental hip chondrolysis model

Author Kitadai, Humberto Ken Autor UNIFESP Google Scholar
Takahashi, Helio Kiyoshi Autor UNIFESP Google Scholar
Straus, Anita Hilda Autor UNIFESP Google Scholar
Ibanez, J. F. Google Scholar
Lucas, R. Google Scholar
Kitadai, Fabio Takashi Autor UNIFESP Google Scholar
Milani, Carlo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Metropolitana Unida
Universidade de São Paulo (USP)
Abstract We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin inhibitor, diacerein (DAR) in the ensuing articular cartilage lesion. Twenty immature beagles were submitted to a surgical K-wire implantation in the hip with the material left in the joint space for 6 months. Twelve animals were sacrificed for histological and biochemical tests. Eight animals were sacrificed at 10 months (half of them treated with DAR) and analyzed by scanning electron microscopy (SEM) and biochemistry of the articular cartilage. Preoperative and monthly C3 and C4 complement and immunoglobulins serum levels were determined. the histological and the electrophoretic profile changes were significative at 6 months. At 10 months the migration profile (CaCl2) recovered to normal levels in the operated hip and the SEM scores for the acetabulum were similar to the non operated control hip after treatment. the serum level of IgA was elevated at the 4th and 6th month postoperatively. the persistence of a metallic implant resulted in degenerative changes parallel to that described for hip chondrolysis as a complication of in-situ pinning; and the cartilage lesion improved with DAR treatment. (c) 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Keywords chondrolysis
experimental
diacerein
biochemistry
scanning electron microscopy
Language English
Date 2006-06-01
Published in Journal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 24, n. 6, p. 1240-1248, 2006.
ISSN 0736-0266 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1240-1248
Origin http://dx.doi.org/10.1002/jor.20180
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000237825600015
URI http://repositorio.unifesp.br/handle/11600/28913

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