Is hepatitis C more aggressive in renal transplant patients than in patients with end-stage renal disease?

Is hepatitis C more aggressive in renal transplant patients than in patients with end-stage renal disease?

Autor Perez, R. M. Google Scholar
Ferreira, ASP Google Scholar
Medina-Pestana, J. O. Google Scholar
Cendoroglo Neto, Miguel Autor UNIFESP Google Scholar
Lanzoni, V. P. Google Scholar
Silva, AEB Google Scholar
Ferraz, MLG Google Scholar
Instituição Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Resumo Background: the eventual impact of immunosuppression on the natural history of hepatitis C virus (HCV) infection in patients with end-stage renal disease (ESRD) is still unknown because of the lack of comparative data for HCV-infected patients with ESRD and renal transplant patients. the aim of this study was to compare the biochemical and histological characteristics of chronic HCV infection in renal transplants patients and ESRD patients undergoing hemodialysis.Methods: Thirty-eight renal transplant patients and 38 ESRD patients undergoing hemodialysis who were chronically infected with HCV and were matched for gender, age at infection, and estimated time of infection were included in the study. the groups were compared regarding laboratory and histological variables.Results: Renal transplant patients showed similar alanine aminotransferase and higher gamma-glutamyltransferase levels (P = 0.05) when compared with ESRD patients. Comparative analysis of histological variables revealed a higher proportion of cases with septal fibrosis (P = 0.04) and confluent necrosis (P = 0.01) among transplant-recipient patients. No difference between groups was observed regarding the intensity of portal and periportal inflammatory infiltrates. Steatosis was more prevalent among transplant-recipient patients (P < 0.001). There was no difference between groups regarding the prevalence of lymphoid aggregates or bile duct injury.Conclusion: Renal transplant patients had a larger proportion of cases with septal fibrosis and confluent necrosis than did ESRD patients, suggesting that renal transplantation might modify the natural history of hepatitis C in ESRD patients, leading to a more aggressive liver disease.
Assunto end-stage renal disease (ESRD)
hemodialysis
hepatitis C
kidney transplantation
liver biopsy
Idioma Inglês
Data 2006-05-01
Publicado em Journal of Clinical Gastroenterology. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 5, p. 444-448, 2006.
ISSN 0192-0790 (Sherpa/Romeo, fator de impacto)
Editor Lippincott Williams & Wilkins
Extensão 444-448
Fonte http://dx.doi.org/10.1097/00004836-200605000-00016
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000237742900016
URI http://repositorio.unifesp.br/handle/11600/28896

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