Clinical and microbiological aspects of candidemia due to Candida parapsilosis in Brazilian tertiary care hospitals

Clinical and microbiological aspects of candidemia due to Candida parapsilosis in Brazilian tertiary care hospitals

Autor Brito, Ligia R. Google Scholar
Guimaraes, Thais Google Scholar
Nucci, Marcio Google Scholar
Rosas, Robert C. Google Scholar
Almeida, Leila Paula Google Scholar
Matta, Daniel Archimedes da Autor UNIFESP Google Scholar
Colombo, Arnaldo L. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Serv Publ Estadual São Paulo
Hosp Beneficencia Portuguesa
Casa Saude Santa Marcelina
Universidade Federal do Rio de Janeiro (UFRJ)
Resumo In order to characterize the epidemiology, microbiology and outcome of candidemia due to Candida parapsilosis, we examined a database of 282 episodes of candidemia prospectively collected from four tertiary care hospitals in São Paulo, Brazil between March 2002 and February 2003, and compared the characteristics of patients with candidemia due to C. parapsilosis (n = 64) with those caused by Candida albicans (n = 107). C. parapsilosis candidemia was associated with neutropenia (p = 0.005), tunneled central venous catheter (p = 0.005) and cancer chemotherapy (p = 0.03). By multivariate analysis, candidemia due to C. parapsilosis was associated with the presence of a tunneled central venous catheter (relative risk 3.71, 95% confidence interval 1.28-10.70). Except for a single isolate of C. parapsilosis that exhibited MIC > 1 mu g/ml to amphotericin B, no resistance was observed in 166 isolates tested against fluconazole, itraconazole, 5-flucytosine and amphotericin B. the caspofungin MIC values of C. parapsilosis isolates were significantly higher than those exhibited by C. albicans isolates (p < 0.001). the overall mortality of patients with candidemia due to C. parapsilosis was significantly lower (45% vs. 62%, p = 0.03). the association between C. parapsilosis candidemia and a tunneled central venous catheter supports the idea that the main mode of acquisition of C. parapsilosis is from an external source.
Assunto candidemia
Candida parapsilosis
nosocomial infection
antifungal resistance
caspofungin
Idioma Inglês
Data 2006-05-01
Publicado em Medical Mycology. Abingdon: Taylor & Francis Ltd, v. 44, n. 3, p. 261-266, 2006.
ISSN 1369-3786 (Sherpa/Romeo, fator de impacto)
Editor Taylor & Francis Ltd
Extensão 261-266
Fonte http://dx.doi.org/10.1080/13693780500421476
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000238878100009
URI http://repositorio.unifesp.br/handle/11600/28895

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